Using the Drosophila Transcriptional Reporter of Intracellular Calcium (TRIC) to examine lasting ethanol-induced changes in neuroexcitability

The Drosophila transcriptional reporter of intracellular calcium (TRIC) is a genetic tool used to measure lasting changes in neuroexcitability. Both pan-neuronal and dopaminergic cells were examined with TRIC to test the hypothesis that ethanol exposure causes lasting changes in adult brain neuroexc...

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Detalles Bibliográficos
Autores principales: Merriman, Kahlan, Petruccelli, Emily
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Caltech Library 2021
Materias:
Negative Result
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8461458/
https://www.ncbi.nlm.nih.gov/pubmed/34585103
http://dx.doi.org/10.17912/micropub.biology.000477
Descripción
Sumario:The Drosophila transcriptional reporter of intracellular calcium (TRIC) is a genetic tool used to measure lasting changes in neuroexcitability. Both pan-neuronal and dopaminergic cells were examined with TRIC to test the hypothesis that ethanol exposure causes lasting changes in adult brain neuroexcitability. We found little to no impact on TRIC signal following acute and repeated ethanol vapor exposures. This work shows that TRIC may be useful in future investigations such as developmental or chronic drug exposure paradigms.

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