Using the Drosophila Transcriptional Reporter of Intracellular Calcium (TRIC) to examine lasting ethanol-induced changes in neuroexcitability

The Drosophila transcriptional reporter of intracellular calcium (TRIC) is a genetic tool used to measure lasting changes in neuroexcitability. Both pan-neuronal and dopaminergic cells were examined with TRIC to test the hypothesis that ethanol exposure causes lasting changes in adult brain neuroexc...

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Detalles Bibliográficos
Autores principales: Merriman, Kahlan, Petruccelli, Emily
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Caltech Library 2021
Materias:
Negative Result
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8461458/
https://www.ncbi.nlm.nih.gov/pubmed/34585103
http://dx.doi.org/10.17912/micropub.biology.000477
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author Merriman, Kahlan
Petruccelli, Emily
author_facet Merriman, Kahlan
Petruccelli, Emily
author_sort Merriman, Kahlan
collection PubMed
description The Drosophila transcriptional reporter of intracellular calcium (TRIC) is a genetic tool used to measure lasting changes in neuroexcitability. Both pan-neuronal and dopaminergic cells were examined with TRIC to test the hypothesis that ethanol exposure causes lasting changes in adult brain neuroexcitability. We found little to no impact on TRIC signal following acute and repeated ethanol vapor exposures. This work shows that TRIC may be useful in future investigations such as developmental or chronic drug exposure paradigms.
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spelling pubmed-84614582021-09-27 Using the Drosophila Transcriptional Reporter of Intracellular Calcium (TRIC) to examine lasting ethanol-induced changes in neuroexcitability Merriman, Kahlan Petruccelli, Emily MicroPubl Biol Negative Result The Drosophila transcriptional reporter of intracellular calcium (TRIC) is a genetic tool used to measure lasting changes in neuroexcitability. Both pan-neuronal and dopaminergic cells were examined with TRIC to test the hypothesis that ethanol exposure causes lasting changes in adult brain neuroexcitability. We found little to no impact on TRIC signal following acute and repeated ethanol vapor exposures. This work shows that TRIC may be useful in future investigations such as developmental or chronic drug exposure paradigms. Caltech Library 2021-09-23 /pmc/articles/PMC8461458/ /pubmed/34585103 http://dx.doi.org/10.17912/micropub.biology.000477 Text en Copyright: © 2021 by the authors https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Negative Result
Merriman, Kahlan
Petruccelli, Emily
Using the Drosophila Transcriptional Reporter of Intracellular Calcium (TRIC) to examine lasting ethanol-induced changes in neuroexcitability
title Using the Drosophila Transcriptional Reporter of Intracellular Calcium (TRIC) to examine lasting ethanol-induced changes in neuroexcitability
title_full Using the Drosophila Transcriptional Reporter of Intracellular Calcium (TRIC) to examine lasting ethanol-induced changes in neuroexcitability
title_fullStr Using the Drosophila Transcriptional Reporter of Intracellular Calcium (TRIC) to examine lasting ethanol-induced changes in neuroexcitability
title_full_unstemmed Using the Drosophila Transcriptional Reporter of Intracellular Calcium (TRIC) to examine lasting ethanol-induced changes in neuroexcitability
title_short Using the Drosophila Transcriptional Reporter of Intracellular Calcium (TRIC) to examine lasting ethanol-induced changes in neuroexcitability
title_sort using the drosophila transcriptional reporter of intracellular calcium (tric) to examine lasting ethanol-induced changes in neuroexcitability
topic Negative Result
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8461458/
https://www.ncbi.nlm.nih.gov/pubmed/34585103
http://dx.doi.org/10.17912/micropub.biology.000477
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