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Brain-derived neurotrophic factor in autoimmune inflammatory diseases (Review)
Numerous recent studies reported that brain-derived neurotrophic factor (BDNF) also exists in the peripheral blood to regulate the proliferation, differentiation and survival of lymphocytes. Besides the role of BDNF in neuron repair, circulatory BDNF also enhances the proliferation and reduces apopt...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8461510/ https://www.ncbi.nlm.nih.gov/pubmed/34630647 http://dx.doi.org/10.3892/etm.2021.10727 |
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author | Wang, Ningning Tian, Bailing |
author_facet | Wang, Ningning Tian, Bailing |
author_sort | Wang, Ningning |
collection | PubMed |
description | Numerous recent studies reported that brain-derived neurotrophic factor (BDNF) also exists in the peripheral blood to regulate the proliferation, differentiation and survival of lymphocytes. Besides the role of BDNF in neuron repair, circulatory BDNF also enhances the proliferation and reduces apoptosis of lymphocytes. Peripheral lymphocytes express both BDNF and its receptors. Increasing evidence has indicated that altered BDNF serum levels significantly affect patients with autoimmune inflammatory diseases and may also be linked to the pathogenesis of diseases. For instance, systemic lupus erythematosus, an autoimmune inflammatory disease involving multiple organs, is frequently linked to altered B lymphocyte function, imbalance of T-cell subpopulations and loss of immune tolerance, which dysregulates the immune regulatory network with excessive secretion of inflammatory cytokines. The present review summarized studies that suggest a potential link between circulatory BDNF and autoimmune inflammatory diseases. |
format | Online Article Text |
id | pubmed-8461510 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-84615102021-10-07 Brain-derived neurotrophic factor in autoimmune inflammatory diseases (Review) Wang, Ningning Tian, Bailing Exp Ther Med Review Numerous recent studies reported that brain-derived neurotrophic factor (BDNF) also exists in the peripheral blood to regulate the proliferation, differentiation and survival of lymphocytes. Besides the role of BDNF in neuron repair, circulatory BDNF also enhances the proliferation and reduces apoptosis of lymphocytes. Peripheral lymphocytes express both BDNF and its receptors. Increasing evidence has indicated that altered BDNF serum levels significantly affect patients with autoimmune inflammatory diseases and may also be linked to the pathogenesis of diseases. For instance, systemic lupus erythematosus, an autoimmune inflammatory disease involving multiple organs, is frequently linked to altered B lymphocyte function, imbalance of T-cell subpopulations and loss of immune tolerance, which dysregulates the immune regulatory network with excessive secretion of inflammatory cytokines. The present review summarized studies that suggest a potential link between circulatory BDNF and autoimmune inflammatory diseases. D.A. Spandidos 2021-11 2021-09-13 /pmc/articles/PMC8461510/ /pubmed/34630647 http://dx.doi.org/10.3892/etm.2021.10727 Text en Copyright: © Wang et al. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Review Wang, Ningning Tian, Bailing Brain-derived neurotrophic factor in autoimmune inflammatory diseases (Review) |
title | Brain-derived neurotrophic factor in autoimmune inflammatory diseases (Review) |
title_full | Brain-derived neurotrophic factor in autoimmune inflammatory diseases (Review) |
title_fullStr | Brain-derived neurotrophic factor in autoimmune inflammatory diseases (Review) |
title_full_unstemmed | Brain-derived neurotrophic factor in autoimmune inflammatory diseases (Review) |
title_short | Brain-derived neurotrophic factor in autoimmune inflammatory diseases (Review) |
title_sort | brain-derived neurotrophic factor in autoimmune inflammatory diseases (review) |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8461510/ https://www.ncbi.nlm.nih.gov/pubmed/34630647 http://dx.doi.org/10.3892/etm.2021.10727 |
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