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The Unexplored Importance of Fleeting Chiral Intermediates in Enzyme-Catalyzed Reactions

[Image: see text] Decades of extensive research efforts by biochemists, organic chemists, and protein engineers have led to an understanding of the basic mechanisms of essentially all known types of enzymes, but in a formidable number of cases an essential aspect has been overlooked. The occurrence...

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Detalles Bibliográficos
Autores principales: Reetz, Manfred T., Garcia-Borràs, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8461649/
https://www.ncbi.nlm.nih.gov/pubmed/34491742
http://dx.doi.org/10.1021/jacs.1c04551