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Role and Mechanism of Vitamin A Metabolism in the Pathophysiology of Parkinson’s Disease

Evidence shows that altered retinoic acid signaling may contribute to the pathogenesis and pathophysiology of Parkinson’s disease (PD). Retinoic acid is the bioactive derivative of the lipophilic vitamin A. Vitamin A is involved in several important homeostatic processes, such as cell differentiatio...

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Autores principales: Marie, Anaıs, Darricau, Morgane, Touyarot, Katia, Parr-Brownlie, Louise C., Bosch-Bouju, Clémentine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8461657/
https://www.ncbi.nlm.nih.gov/pubmed/34120916
http://dx.doi.org/10.3233/JPD-212671
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author Marie, Anaıs
Darricau, Morgane
Touyarot, Katia
Parr-Brownlie, Louise C.
Bosch-Bouju, Clémentine
author_facet Marie, Anaıs
Darricau, Morgane
Touyarot, Katia
Parr-Brownlie, Louise C.
Bosch-Bouju, Clémentine
author_sort Marie, Anaıs
collection PubMed
description Evidence shows that altered retinoic acid signaling may contribute to the pathogenesis and pathophysiology of Parkinson’s disease (PD). Retinoic acid is the bioactive derivative of the lipophilic vitamin A. Vitamin A is involved in several important homeostatic processes, such as cell differentiation, antioxidant activity, inflammation and neuronal plasticity. The role of vitamin A and its derivatives in the pathogenesis and pathophysiology of neurodegenerative diseases, and their potential as therapeutics, has drawn attention for more than 10 years. However, the literature sits in disparate fields. Vitamin A could act at the crossroad of multiple environmental and genetic factors of PD. The purpose of this review is to outline what is known about the role of vitamin A metabolism in the pathogenesis and pathophysiology of PD. We examine key biological systems and mechanisms that are under the control of vitamin A and its derivatives, which are (or could be) exploited for therapeutic potential in PD: the survival of dopaminergic neurons, oxidative stress, neuroinflammation, circadian rhythms, homeostasis of the enteric nervous system, and hormonal systems. We focus on the pivotal role of ALDH1A1, an enzyme expressed by dopaminergic neurons for the detoxification of these neurons, which is under the control of retinoic acid. By providing an integrated summary, this review will guide future studies on the potential role of vitamin A in the management of symptoms, health and wellbeing for PD patients.
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spelling pubmed-84616572021-10-08 Role and Mechanism of Vitamin A Metabolism in the Pathophysiology of Parkinson’s Disease Marie, Anaıs Darricau, Morgane Touyarot, Katia Parr-Brownlie, Louise C. Bosch-Bouju, Clémentine J Parkinsons Dis Review Evidence shows that altered retinoic acid signaling may contribute to the pathogenesis and pathophysiology of Parkinson’s disease (PD). Retinoic acid is the bioactive derivative of the lipophilic vitamin A. Vitamin A is involved in several important homeostatic processes, such as cell differentiation, antioxidant activity, inflammation and neuronal plasticity. The role of vitamin A and its derivatives in the pathogenesis and pathophysiology of neurodegenerative diseases, and their potential as therapeutics, has drawn attention for more than 10 years. However, the literature sits in disparate fields. Vitamin A could act at the crossroad of multiple environmental and genetic factors of PD. The purpose of this review is to outline what is known about the role of vitamin A metabolism in the pathogenesis and pathophysiology of PD. We examine key biological systems and mechanisms that are under the control of vitamin A and its derivatives, which are (or could be) exploited for therapeutic potential in PD: the survival of dopaminergic neurons, oxidative stress, neuroinflammation, circadian rhythms, homeostasis of the enteric nervous system, and hormonal systems. We focus on the pivotal role of ALDH1A1, an enzyme expressed by dopaminergic neurons for the detoxification of these neurons, which is under the control of retinoic acid. By providing an integrated summary, this review will guide future studies on the potential role of vitamin A in the management of symptoms, health and wellbeing for PD patients. IOS Press 2021-08-02 /pmc/articles/PMC8461657/ /pubmed/34120916 http://dx.doi.org/10.3233/JPD-212671 Text en © 2021 – The authors. Published by IOS Press https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) License (https://creativecommons.org/licenses/by-nc/4.0/) , which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Marie, Anaıs
Darricau, Morgane
Touyarot, Katia
Parr-Brownlie, Louise C.
Bosch-Bouju, Clémentine
Role and Mechanism of Vitamin A Metabolism in the Pathophysiology of Parkinson’s Disease
title Role and Mechanism of Vitamin A Metabolism in the Pathophysiology of Parkinson’s Disease
title_full Role and Mechanism of Vitamin A Metabolism in the Pathophysiology of Parkinson’s Disease
title_fullStr Role and Mechanism of Vitamin A Metabolism in the Pathophysiology of Parkinson’s Disease
title_full_unstemmed Role and Mechanism of Vitamin A Metabolism in the Pathophysiology of Parkinson’s Disease
title_short Role and Mechanism of Vitamin A Metabolism in the Pathophysiology of Parkinson’s Disease
title_sort role and mechanism of vitamin a metabolism in the pathophysiology of parkinson’s disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8461657/
https://www.ncbi.nlm.nih.gov/pubmed/34120916
http://dx.doi.org/10.3233/JPD-212671
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