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Widespread Reduced Density of Noradrenergic Locus Coeruleus Axons in the App Knock-In Mouse Model of Amyloid-β Amyloidosis

BACKGROUND: The locus coeruleus (LC), a brainstem nucleus comprising noradrenergic neurons, is one of the earliest regions affected by Alzheimer’s disease (AD). Amyloid-β (Aβ) pathology in the cortex in AD is thought to exacerbate the age-related loss of LC neurons, which may lead to cortical tau pa...

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Detalles Bibliográficos
Autores principales:	Sakakibara, Yasufumi, Hirota, Yu, Ibaraki, Kyoko, Takei, Kimi, Chikamatsu, Sachie, Tsubokawa, Yoko, Saito, Takashi, Saido, Takaomi C., Sekiya, Michiko, Iijima, Koichi M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	IOS Press 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8461671/ https://www.ncbi.nlm.nih.gov/pubmed/34180416 http://dx.doi.org/10.3233/JAD-210385

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