Rare case of COVID-19 vaccine-associated intracranial haemorrhage with venous sinus thrombosis

Vaccine-induced immune thrombotic thrombocytopenia (VITT) is a relatively novel term which describes patients who have developed a low platelet count and prothrombotic tendencies secondary to receiving a vaccine. The concept has been derived from the well-established phenomenon of heparin-induced th...

Descripción completa

Detalles Bibliográficos
Autores principales: Purkayastha, Pujon, Mckechnie, Charlie, Kalkur, Pallavi, Scully, Marie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8461674/
https://www.ncbi.nlm.nih.gov/pubmed/34556531
http://dx.doi.org/10.1136/bcr-2021-245092
_version_ 1784572038730481664
author Purkayastha, Pujon
Mckechnie, Charlie
Kalkur, Pallavi
Scully, Marie
author_facet Purkayastha, Pujon
Mckechnie, Charlie
Kalkur, Pallavi
Scully, Marie
author_sort Purkayastha, Pujon
collection PubMed
description Vaccine-induced immune thrombotic thrombocytopenia (VITT) is a relatively novel term which describes patients who have developed a low platelet count and prothrombotic tendencies secondary to receiving a vaccine. The concept has been derived from the well-established phenomenon of heparin-induced thrombocytopenia, and several cases of VITT have now been reported in patients who have received the AstraZeneca (ChAdOx1 nCov-19) vaccine. Unfortunately, some of these patients have gone on to develop intracranial venous sinus thrombosis. We present a case of VITT-associated sinus thrombosis secondary to the AstraZeneca (ChAdOx1 nCov-19) vaccine, which was complicated by a large intracerebral haemorrhage.
format Online
Article
Text
id pubmed-8461674
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher BMJ Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-84616742021-10-08 Rare case of COVID-19 vaccine-associated intracranial haemorrhage with venous sinus thrombosis Purkayastha, Pujon Mckechnie, Charlie Kalkur, Pallavi Scully, Marie BMJ Case Rep Case Report Vaccine-induced immune thrombotic thrombocytopenia (VITT) is a relatively novel term which describes patients who have developed a low platelet count and prothrombotic tendencies secondary to receiving a vaccine. The concept has been derived from the well-established phenomenon of heparin-induced thrombocytopenia, and several cases of VITT have now been reported in patients who have received the AstraZeneca (ChAdOx1 nCov-19) vaccine. Unfortunately, some of these patients have gone on to develop intracranial venous sinus thrombosis. We present a case of VITT-associated sinus thrombosis secondary to the AstraZeneca (ChAdOx1 nCov-19) vaccine, which was complicated by a large intracerebral haemorrhage. BMJ Publishing Group 2021-09-23 /pmc/articles/PMC8461674/ /pubmed/34556531 http://dx.doi.org/10.1136/bcr-2021-245092 Text en © BMJ Publishing Group Limited 2021. No commercial re-use. See rights and permissions. Published by BMJ. https://bmj.com/coronavirus/usageThis article is made freely available for use in accordance with BMJ’s website terms and conditions for the duration of the covid-19 pandemic or until otherwise determined by BMJ. You may use, download and print the article for any lawful, non-commercial purpose (including text and data mining) provided that all copyright notices and trade marks are retained.
spellingShingle Case Report
Purkayastha, Pujon
Mckechnie, Charlie
Kalkur, Pallavi
Scully, Marie
Rare case of COVID-19 vaccine-associated intracranial haemorrhage with venous sinus thrombosis
title Rare case of COVID-19 vaccine-associated intracranial haemorrhage with venous sinus thrombosis
title_full Rare case of COVID-19 vaccine-associated intracranial haemorrhage with venous sinus thrombosis
title_fullStr Rare case of COVID-19 vaccine-associated intracranial haemorrhage with venous sinus thrombosis
title_full_unstemmed Rare case of COVID-19 vaccine-associated intracranial haemorrhage with venous sinus thrombosis
title_short Rare case of COVID-19 vaccine-associated intracranial haemorrhage with venous sinus thrombosis
title_sort rare case of covid-19 vaccine-associated intracranial haemorrhage with venous sinus thrombosis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8461674/
https://www.ncbi.nlm.nih.gov/pubmed/34556531
http://dx.doi.org/10.1136/bcr-2021-245092
work_keys_str_mv AT purkayasthapujon rarecaseofcovid19vaccineassociatedintracranialhaemorrhagewithvenoussinusthrombosis
AT mckechniecharlie rarecaseofcovid19vaccineassociatedintracranialhaemorrhagewithvenoussinusthrombosis
AT kalkurpallavi rarecaseofcovid19vaccineassociatedintracranialhaemorrhagewithvenoussinusthrombosis
AT scullymarie rarecaseofcovid19vaccineassociatedintracranialhaemorrhagewithvenoussinusthrombosis