Glucocerebrosidase Activity is Reduced in Cryopreserved Parkinson’s Disease Patient Monocytes and Inversely Correlates with Motor Severity

BACKGROUND: Reduced activity of lysosomal glucocerebrosidase is found in brain tissue from Parkinson’s disease patients. Glucocerebrosidase is also highly expressed in peripheral blood monocytes where its activity is decreased in Parkinson’s disease patients, even in the absence of GBA mutation. OBJ...

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Detalles Bibliográficos
Autores principales: Hughes, Laura P., Pereira, Marilia M.M., Hammond, Deborah A., Kwok, John B., Halliday, Glenda M., Lewis, Simon J.G., Dzamko, Nicolas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2021
Materias:
Research Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8461681/
https://www.ncbi.nlm.nih.gov/pubmed/33935104
http://dx.doi.org/10.3233/JPD-202508

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