LRRK2 Kinase Activity Does Not Alter Cell-Autonomous Tau Pathology Development in Primary Neurons

BACKGROUND: Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of familial Parkinson’s disease (PD) and are also associated with genetic risk in idiopathic PD. Mutations in LRRK2, including the most common p.G2019S lead to elevated kinase activity, making LRRK2 kinase inhibi...

Descripción completa

Detalles Bibliográficos
Autores principales: Henderson, Michael X., Changolkar, Lakshmi, Trojanowski, John Q., Lee, Virginia M.Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2021
Materias:
Research Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8461695/
https://www.ncbi.nlm.nih.gov/pubmed/33720852
http://dx.doi.org/10.3233/JPD-212562

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8461695/
https://www.ncbi.nlm.nih.gov/pubmed/33720852
http://dx.doi.org/10.3233/JPD-212562

Ejemplares similares