Effects of Alpha-Synuclein Targeted Antisense Oligonucleotides on Lewy Body-Like Pathology and Behavioral Disturbances Induced by Injections of Pre-Formed Fibrils in the Mouse Motor Cortex

BACKGROUND: Alpha-synuclein (αsyn) characterizes neurodegenerative diseases known as synucleinopathies. The phosphorylated form (psyn) is the primary component of protein aggregates known as Lewy bodies (LBs), which are the hallmark of diseases such as Parkinson’s disease (PD). Synucleinopathies mig...

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Detalles Bibliográficos
Autores principales: Boutros, Sydney Weber, Raber, Jacob, Unni, Vivek K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2021
Materias:
Research Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8461707/
https://www.ncbi.nlm.nih.gov/pubmed/34057097
http://dx.doi.org/10.3233/JPD-212566

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8461707/
https://www.ncbi.nlm.nih.gov/pubmed/34057097
http://dx.doi.org/10.3233/JPD-212566

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