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Modular Integration of Hydrogel Neural Interfaces
[Image: see text] Thermal drawing has been recently leveraged to yield multifunctional, fiber-based neural probes at near kilometer length scales. Despite its promise, the widespread adoption of this approach has been impeded by (1) material compatibility requirements and (2) labor-intensive interfa...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8461769/ https://www.ncbi.nlm.nih.gov/pubmed/34584953 http://dx.doi.org/10.1021/acscentsci.1c00592 |
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author | Tabet, Anthony Antonini, Marc-Joseph Sahasrabudhe, Atharva Park, Jimin Rosenfeld, Dekel Koehler, Florian Yuk, Hyunwoo Hanson, Samuel Stinson, Jordan Stok, Melissa Zhao, Xuanhe Wang, Chun Anikeeva, Polina |
author_facet | Tabet, Anthony Antonini, Marc-Joseph Sahasrabudhe, Atharva Park, Jimin Rosenfeld, Dekel Koehler, Florian Yuk, Hyunwoo Hanson, Samuel Stinson, Jordan Stok, Melissa Zhao, Xuanhe Wang, Chun Anikeeva, Polina |
author_sort | Tabet, Anthony |
collection | PubMed |
description | [Image: see text] Thermal drawing has been recently leveraged to yield multifunctional, fiber-based neural probes at near kilometer length scales. Despite its promise, the widespread adoption of this approach has been impeded by (1) material compatibility requirements and (2) labor-intensive interfacing of functional features to external hardware. Furthermore, in multifunctional fibers, significant volume is occupied by passive polymer cladding that so far has only served structural or electrical insulation purposes. In this article, we report a rapid, robust, and modular approach to creating multifunctional fiber-based neural interfaces using a solvent evaporation or entrapment-driven (SEED) integration process. This process brings together electrical, optical, and microfluidic modalities all encased within a copolymer comprised of water-soluble poly(ethylene glycol) tethered to water-insoluble poly(urethane) (PU-PEG). We employ these devices for simultaneous optogenetics and electrophysiology and demonstrate that multifunctional neural probes can be used to deliver cellular cargo with high viability. Upon exposure to water, PU-PEG cladding spontaneously forms a hydrogel, which in addition to enabling integration of modalities, can harbor small molecules and nanomaterials that can be released into local tissue following implantation. We also synthesized a custom nanodroplet forming block polymer and demonstrated that embedding such materials within the hydrogel cladding of our probes enables delivery of hydrophobic small molecules in vitro and in vivo. Our approach widens the chemical toolbox and expands the capabilities of multifunctional neural interfaces. |
format | Online Article Text |
id | pubmed-8461769 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | American Chemical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-84617692021-09-27 Modular Integration of Hydrogel Neural Interfaces Tabet, Anthony Antonini, Marc-Joseph Sahasrabudhe, Atharva Park, Jimin Rosenfeld, Dekel Koehler, Florian Yuk, Hyunwoo Hanson, Samuel Stinson, Jordan Stok, Melissa Zhao, Xuanhe Wang, Chun Anikeeva, Polina ACS Cent Sci [Image: see text] Thermal drawing has been recently leveraged to yield multifunctional, fiber-based neural probes at near kilometer length scales. Despite its promise, the widespread adoption of this approach has been impeded by (1) material compatibility requirements and (2) labor-intensive interfacing of functional features to external hardware. Furthermore, in multifunctional fibers, significant volume is occupied by passive polymer cladding that so far has only served structural or electrical insulation purposes. In this article, we report a rapid, robust, and modular approach to creating multifunctional fiber-based neural interfaces using a solvent evaporation or entrapment-driven (SEED) integration process. This process brings together electrical, optical, and microfluidic modalities all encased within a copolymer comprised of water-soluble poly(ethylene glycol) tethered to water-insoluble poly(urethane) (PU-PEG). We employ these devices for simultaneous optogenetics and electrophysiology and demonstrate that multifunctional neural probes can be used to deliver cellular cargo with high viability. Upon exposure to water, PU-PEG cladding spontaneously forms a hydrogel, which in addition to enabling integration of modalities, can harbor small molecules and nanomaterials that can be released into local tissue following implantation. We also synthesized a custom nanodroplet forming block polymer and demonstrated that embedding such materials within the hydrogel cladding of our probes enables delivery of hydrophobic small molecules in vitro and in vivo. Our approach widens the chemical toolbox and expands the capabilities of multifunctional neural interfaces. American Chemical Society 2021-08-28 2021-09-22 /pmc/articles/PMC8461769/ /pubmed/34584953 http://dx.doi.org/10.1021/acscentsci.1c00592 Text en © 2021 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Tabet, Anthony Antonini, Marc-Joseph Sahasrabudhe, Atharva Park, Jimin Rosenfeld, Dekel Koehler, Florian Yuk, Hyunwoo Hanson, Samuel Stinson, Jordan Stok, Melissa Zhao, Xuanhe Wang, Chun Anikeeva, Polina Modular Integration of Hydrogel Neural Interfaces |
title | Modular Integration of Hydrogel Neural Interfaces |
title_full | Modular Integration of Hydrogel Neural Interfaces |
title_fullStr | Modular Integration of Hydrogel Neural Interfaces |
title_full_unstemmed | Modular Integration of Hydrogel Neural Interfaces |
title_short | Modular Integration of Hydrogel Neural Interfaces |
title_sort | modular integration of hydrogel neural interfaces |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8461769/ https://www.ncbi.nlm.nih.gov/pubmed/34584953 http://dx.doi.org/10.1021/acscentsci.1c00592 |
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