Essential role of DNA-PKcs and plasminogen for the development of doxorubicin-induced glomerular injury in mice

Susceptibility to doxorubicin-induced nephropathy (DIN), a toxic model for the induction of proteinuria in mice, is related to the single-nucleotide polymorphism (SNP) C6418T of the Prkdc gene encoding for the DNA-repair enzyme DNA-PKcs. In addition, plasminogen (Plg) has been reported to play a rol...

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Detalles Bibliográficos
Autores principales: Bohnert, Bernhard N., Gonzalez-Menendez, Irene, Dörffel, Thomas, Schneider, Jonas C., Xiao, Mengyun, Janessa, Andrea, Kalo, M. Zaher, Fehrenbacher, Birgit, Schaller, Martin, Casadei, Nicolas, Amann, Kerstin, Daniel, Christoph, Birkenfeld, Andreas L., Grahammer, Florian, Izem, Lahoucine, Plow, Edward F., Quintanilla-Martinez, Leticia, Artunc, Ferruh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8461821/
https://www.ncbi.nlm.nih.gov/pubmed/34423816
http://dx.doi.org/10.1242/dmm.049038

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