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Prevalence and risk factors of chronic kidney disease in an HIV positive Mexican cohort

BACKGROUND: HIV subjects have several kidney pathologies, like HIV-associated nephropathy or antiretroviral therapy injury, among others. The global prevalence of Chronic Kidney Disease (CKD) is 8–16%; however, in HIV subjects, the prevalence varies between geographic regions (2–38%). The aim was to...

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Autores principales: Valdivia-Cerda, Verónica, Alvarez-Zavala, Monserrat, Sánchez-Reyes, Karina, Cabrera-Silva, Rodolfo I., Ruiz-Herrera, Vida V., Loza-Salazar, Aldo D., Martínez-Ayala, Pedro, Vázquez-Limón, Juan C., García-García, Guillermo, Andrade-Villanueva, Jaime F., González-Hernández, Luz A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8461868/
https://www.ncbi.nlm.nih.gov/pubmed/34556049
http://dx.doi.org/10.1186/s12882-021-02526-4
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author Valdivia-Cerda, Verónica
Alvarez-Zavala, Monserrat
Sánchez-Reyes, Karina
Cabrera-Silva, Rodolfo I.
Ruiz-Herrera, Vida V.
Loza-Salazar, Aldo D.
Martínez-Ayala, Pedro
Vázquez-Limón, Juan C.
García-García, Guillermo
Andrade-Villanueva, Jaime F.
González-Hernández, Luz A.
author_facet Valdivia-Cerda, Verónica
Alvarez-Zavala, Monserrat
Sánchez-Reyes, Karina
Cabrera-Silva, Rodolfo I.
Ruiz-Herrera, Vida V.
Loza-Salazar, Aldo D.
Martínez-Ayala, Pedro
Vázquez-Limón, Juan C.
García-García, Guillermo
Andrade-Villanueva, Jaime F.
González-Hernández, Luz A.
author_sort Valdivia-Cerda, Verónica
collection PubMed
description BACKGROUND: HIV subjects have several kidney pathologies, like HIV-associated nephropathy or antiretroviral therapy injury, among others. The global prevalence of Chronic Kidney Disease (CKD) is 8–16%; however, in HIV subjects, the prevalence varies between geographic regions (2–38%). The aim was to determine the prevalence of CKD and identify the associated risk factors. METHODS: A longitudinal descriptive study was carried out at the 'Hospital Civil de Guadalajara' Feb'18 – Jan'19. Basal clinical, demographic, opportunistic infections (OI), and laboratory data were obtained at months 0 and 3; inclusion criteria were ≥ 18 years old, naïve HIV + , urine albumin/creatinine ratio, serum creatinine & urine test, and signed informed consent. Descriptive and multiple logistic regression statistical analyses were made. RESULTS: One hundred twenty subjects were included; 92.5% were male, 33 ± 9.5 years, 60% consumed tobacco, 73% alcohol, and 59% some type of drug. The CKD prevalence was 15.8%. CKD patients had a higher risk of hepatitis C virus coinfection, Relative Risk (RR):5.9; HCV infection, RR:4.3; ≥ 30 years old, RR:3.9; C clinical-stage, RR:3.5; CD4(+) T cells count < 200 cells/μL, RR: 2.4; and HIV-1 viral load ≥ 100,000 cop/mL, RR: 2.7. CONCLUSIONS: Our study showed a higher CKD prevalence in patients with HIV; higher CKD development with coinfections as Hepatitis C Virus and Mycobacterium tuberculosis. The identification and prompt management of CKD and coinfections should be considered to avoid the progression and to delay renal replacement therapy as long as possible.
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spelling pubmed-84618682021-09-24 Prevalence and risk factors of chronic kidney disease in an HIV positive Mexican cohort Valdivia-Cerda, Verónica Alvarez-Zavala, Monserrat Sánchez-Reyes, Karina Cabrera-Silva, Rodolfo I. Ruiz-Herrera, Vida V. Loza-Salazar, Aldo D. Martínez-Ayala, Pedro Vázquez-Limón, Juan C. García-García, Guillermo Andrade-Villanueva, Jaime F. González-Hernández, Luz A. BMC Nephrol Research BACKGROUND: HIV subjects have several kidney pathologies, like HIV-associated nephropathy or antiretroviral therapy injury, among others. The global prevalence of Chronic Kidney Disease (CKD) is 8–16%; however, in HIV subjects, the prevalence varies between geographic regions (2–38%). The aim was to determine the prevalence of CKD and identify the associated risk factors. METHODS: A longitudinal descriptive study was carried out at the 'Hospital Civil de Guadalajara' Feb'18 – Jan'19. Basal clinical, demographic, opportunistic infections (OI), and laboratory data were obtained at months 0 and 3; inclusion criteria were ≥ 18 years old, naïve HIV + , urine albumin/creatinine ratio, serum creatinine & urine test, and signed informed consent. Descriptive and multiple logistic regression statistical analyses were made. RESULTS: One hundred twenty subjects were included; 92.5% were male, 33 ± 9.5 years, 60% consumed tobacco, 73% alcohol, and 59% some type of drug. The CKD prevalence was 15.8%. CKD patients had a higher risk of hepatitis C virus coinfection, Relative Risk (RR):5.9; HCV infection, RR:4.3; ≥ 30 years old, RR:3.9; C clinical-stage, RR:3.5; CD4(+) T cells count < 200 cells/μL, RR: 2.4; and HIV-1 viral load ≥ 100,000 cop/mL, RR: 2.7. CONCLUSIONS: Our study showed a higher CKD prevalence in patients with HIV; higher CKD development with coinfections as Hepatitis C Virus and Mycobacterium tuberculosis. The identification and prompt management of CKD and coinfections should be considered to avoid the progression and to delay renal replacement therapy as long as possible. BioMed Central 2021-09-23 /pmc/articles/PMC8461868/ /pubmed/34556049 http://dx.doi.org/10.1186/s12882-021-02526-4 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Valdivia-Cerda, Verónica
Alvarez-Zavala, Monserrat
Sánchez-Reyes, Karina
Cabrera-Silva, Rodolfo I.
Ruiz-Herrera, Vida V.
Loza-Salazar, Aldo D.
Martínez-Ayala, Pedro
Vázquez-Limón, Juan C.
García-García, Guillermo
Andrade-Villanueva, Jaime F.
González-Hernández, Luz A.
Prevalence and risk factors of chronic kidney disease in an HIV positive Mexican cohort
title Prevalence and risk factors of chronic kidney disease in an HIV positive Mexican cohort
title_full Prevalence and risk factors of chronic kidney disease in an HIV positive Mexican cohort
title_fullStr Prevalence and risk factors of chronic kidney disease in an HIV positive Mexican cohort
title_full_unstemmed Prevalence and risk factors of chronic kidney disease in an HIV positive Mexican cohort
title_short Prevalence and risk factors of chronic kidney disease in an HIV positive Mexican cohort
title_sort prevalence and risk factors of chronic kidney disease in an hiv positive mexican cohort
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8461868/
https://www.ncbi.nlm.nih.gov/pubmed/34556049
http://dx.doi.org/10.1186/s12882-021-02526-4
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