Targeting the DNA damage response enhances CD70 CAR-T cell therapy for renal carcinoma by activating the cGAS-STING pathway

Chimeric antigen receptor T-cell (CAR-T) therapy has shown tremendous success in eradicating hematologic malignancies. However, this success has not yet been extrapolated to solid tumors due to the limited infiltration and persistence of CAR-T cells in the tumor microenvironment (TME). In this study...

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Detalles Bibliográficos
Autores principales: Ji, Feng, Zhang, Fan, Zhang, Miaomiao, Long, Kaili, Xia, Mingyue, Lu, Fei, Li, Enjie, Chen, Jiannan, Li, Jun, Chen, Zhengliang, Jing, Li, Jia, Shaochang, Yang, Rong, Hu, Zhigang, Guo, Zhigang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8461872/
https://www.ncbi.nlm.nih.gov/pubmed/34556152
http://dx.doi.org/10.1186/s13045-021-01168-1

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