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Malignant fibrous histiocytoma of the bone in a traumatic amputation stump: A case report and review of the literature

BACKGROUND: Malignant fibrous histiocytoma (MFH) is one of the most common soft tissue sarcomas among adults. It is characterized by large size, high grade, and biological aggressiveness. There are many reports of MFH after local stimulation, such as bone fracture, implants, and chronic osteomyeliti...

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Autores principales: Zhao, Ke-Yang, Yan, Xu, Yao, Peng-Fei, Mei, Jiong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8462244/
https://www.ncbi.nlm.nih.gov/pubmed/34621848
http://dx.doi.org/10.12998/wjcc.v9.i26.7930
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author Zhao, Ke-Yang
Yan, Xu
Yao, Peng-Fei
Mei, Jiong
author_facet Zhao, Ke-Yang
Yan, Xu
Yao, Peng-Fei
Mei, Jiong
author_sort Zhao, Ke-Yang
collection PubMed
description BACKGROUND: Malignant fibrous histiocytoma (MFH) is one of the most common soft tissue sarcomas among adults. It is characterized by large size, high grade, and biological aggressiveness. There are many reports of MFH after local stimulation, such as bone fracture, implants, and chronic osteomyelitis. In this paper, we report a patient who developed MFH 6 years after amputation, suggesting that wound healing and mechanical force play a role in the local stimulation of this disease. CASE SUMMARY: A 66-year-old man complained of persistent pain in his residual mid-thigh. He had undergone amputation surgery due to a traffic accident 6 years prior. Physical examination showed tenderness but no abnormalities in appearance. X-ray radiographs and magnetic resonance imaging supported the diagnosis of a tumor, and a biopsy confirmed that the lesion was MFH. The patient received neoadjuvant chemotherapy and left hip disarticulation. During the 6-mo follow-up, there were no symptoms of recurrence. CONCLUSION: Postsurgery MFH has been reported before, and many studies have attributed it to the biological effects of implants. Our case report shows that this disease can develop without an implant and thus highlights the importance of local stimulation. The wound-healing process and mechanical force can both promote this tumor, but whether they directly cause MFH needs further investigation.
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spelling pubmed-84622442021-10-06 Malignant fibrous histiocytoma of the bone in a traumatic amputation stump: A case report and review of the literature Zhao, Ke-Yang Yan, Xu Yao, Peng-Fei Mei, Jiong World J Clin Cases Case Report BACKGROUND: Malignant fibrous histiocytoma (MFH) is one of the most common soft tissue sarcomas among adults. It is characterized by large size, high grade, and biological aggressiveness. There are many reports of MFH after local stimulation, such as bone fracture, implants, and chronic osteomyelitis. In this paper, we report a patient who developed MFH 6 years after amputation, suggesting that wound healing and mechanical force play a role in the local stimulation of this disease. CASE SUMMARY: A 66-year-old man complained of persistent pain in his residual mid-thigh. He had undergone amputation surgery due to a traffic accident 6 years prior. Physical examination showed tenderness but no abnormalities in appearance. X-ray radiographs and magnetic resonance imaging supported the diagnosis of a tumor, and a biopsy confirmed that the lesion was MFH. The patient received neoadjuvant chemotherapy and left hip disarticulation. During the 6-mo follow-up, there were no symptoms of recurrence. CONCLUSION: Postsurgery MFH has been reported before, and many studies have attributed it to the biological effects of implants. Our case report shows that this disease can develop without an implant and thus highlights the importance of local stimulation. The wound-healing process and mechanical force can both promote this tumor, but whether they directly cause MFH needs further investigation. Baishideng Publishing Group Inc 2021-09-16 2021-09-16 /pmc/articles/PMC8462244/ /pubmed/34621848 http://dx.doi.org/10.12998/wjcc.v9.i26.7930 Text en ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
spellingShingle Case Report
Zhao, Ke-Yang
Yan, Xu
Yao, Peng-Fei
Mei, Jiong
Malignant fibrous histiocytoma of the bone in a traumatic amputation stump: A case report and review of the literature
title Malignant fibrous histiocytoma of the bone in a traumatic amputation stump: A case report and review of the literature
title_full Malignant fibrous histiocytoma of the bone in a traumatic amputation stump: A case report and review of the literature
title_fullStr Malignant fibrous histiocytoma of the bone in a traumatic amputation stump: A case report and review of the literature
title_full_unstemmed Malignant fibrous histiocytoma of the bone in a traumatic amputation stump: A case report and review of the literature
title_short Malignant fibrous histiocytoma of the bone in a traumatic amputation stump: A case report and review of the literature
title_sort malignant fibrous histiocytoma of the bone in a traumatic amputation stump: a case report and review of the literature
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8462244/
https://www.ncbi.nlm.nih.gov/pubmed/34621848
http://dx.doi.org/10.12998/wjcc.v9.i26.7930
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