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Malignant fibrous histiocytoma of the bone in a traumatic amputation stump: A case report and review of the literature
BACKGROUND: Malignant fibrous histiocytoma (MFH) is one of the most common soft tissue sarcomas among adults. It is characterized by large size, high grade, and biological aggressiveness. There are many reports of MFH after local stimulation, such as bone fracture, implants, and chronic osteomyeliti...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Baishideng Publishing Group Inc
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8462244/ https://www.ncbi.nlm.nih.gov/pubmed/34621848 http://dx.doi.org/10.12998/wjcc.v9.i26.7930 |
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author | Zhao, Ke-Yang Yan, Xu Yao, Peng-Fei Mei, Jiong |
author_facet | Zhao, Ke-Yang Yan, Xu Yao, Peng-Fei Mei, Jiong |
author_sort | Zhao, Ke-Yang |
collection | PubMed |
description | BACKGROUND: Malignant fibrous histiocytoma (MFH) is one of the most common soft tissue sarcomas among adults. It is characterized by large size, high grade, and biological aggressiveness. There are many reports of MFH after local stimulation, such as bone fracture, implants, and chronic osteomyelitis. In this paper, we report a patient who developed MFH 6 years after amputation, suggesting that wound healing and mechanical force play a role in the local stimulation of this disease. CASE SUMMARY: A 66-year-old man complained of persistent pain in his residual mid-thigh. He had undergone amputation surgery due to a traffic accident 6 years prior. Physical examination showed tenderness but no abnormalities in appearance. X-ray radiographs and magnetic resonance imaging supported the diagnosis of a tumor, and a biopsy confirmed that the lesion was MFH. The patient received neoadjuvant chemotherapy and left hip disarticulation. During the 6-mo follow-up, there were no symptoms of recurrence. CONCLUSION: Postsurgery MFH has been reported before, and many studies have attributed it to the biological effects of implants. Our case report shows that this disease can develop without an implant and thus highlights the importance of local stimulation. The wound-healing process and mechanical force can both promote this tumor, but whether they directly cause MFH needs further investigation. |
format | Online Article Text |
id | pubmed-8462244 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Baishideng Publishing Group Inc |
record_format | MEDLINE/PubMed |
spelling | pubmed-84622442021-10-06 Malignant fibrous histiocytoma of the bone in a traumatic amputation stump: A case report and review of the literature Zhao, Ke-Yang Yan, Xu Yao, Peng-Fei Mei, Jiong World J Clin Cases Case Report BACKGROUND: Malignant fibrous histiocytoma (MFH) is one of the most common soft tissue sarcomas among adults. It is characterized by large size, high grade, and biological aggressiveness. There are many reports of MFH after local stimulation, such as bone fracture, implants, and chronic osteomyelitis. In this paper, we report a patient who developed MFH 6 years after amputation, suggesting that wound healing and mechanical force play a role in the local stimulation of this disease. CASE SUMMARY: A 66-year-old man complained of persistent pain in his residual mid-thigh. He had undergone amputation surgery due to a traffic accident 6 years prior. Physical examination showed tenderness but no abnormalities in appearance. X-ray radiographs and magnetic resonance imaging supported the diagnosis of a tumor, and a biopsy confirmed that the lesion was MFH. The patient received neoadjuvant chemotherapy and left hip disarticulation. During the 6-mo follow-up, there were no symptoms of recurrence. CONCLUSION: Postsurgery MFH has been reported before, and many studies have attributed it to the biological effects of implants. Our case report shows that this disease can develop without an implant and thus highlights the importance of local stimulation. The wound-healing process and mechanical force can both promote this tumor, but whether they directly cause MFH needs further investigation. Baishideng Publishing Group Inc 2021-09-16 2021-09-16 /pmc/articles/PMC8462244/ /pubmed/34621848 http://dx.doi.org/10.12998/wjcc.v9.i26.7930 Text en ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
spellingShingle | Case Report Zhao, Ke-Yang Yan, Xu Yao, Peng-Fei Mei, Jiong Malignant fibrous histiocytoma of the bone in a traumatic amputation stump: A case report and review of the literature |
title | Malignant fibrous histiocytoma of the bone in a traumatic amputation stump: A case report and review of the literature |
title_full | Malignant fibrous histiocytoma of the bone in a traumatic amputation stump: A case report and review of the literature |
title_fullStr | Malignant fibrous histiocytoma of the bone in a traumatic amputation stump: A case report and review of the literature |
title_full_unstemmed | Malignant fibrous histiocytoma of the bone in a traumatic amputation stump: A case report and review of the literature |
title_short | Malignant fibrous histiocytoma of the bone in a traumatic amputation stump: A case report and review of the literature |
title_sort | malignant fibrous histiocytoma of the bone in a traumatic amputation stump: a case report and review of the literature |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8462244/ https://www.ncbi.nlm.nih.gov/pubmed/34621848 http://dx.doi.org/10.12998/wjcc.v9.i26.7930 |
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