SARS-CoV-2 Variants in Immunocompromised Patient Given Antibody Monotherapy

A 72-year-old immunocompromised man infected with severe acute respiratory syndrome coronavirus 2 received bamlanivimab monotherapy. Viral evolution was monitored in nasopharyngeal and blood samples by melting curve analysis of single-nucleotide polymorphisms and whole-genome sequencing. Rapid emerg...

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Autores principales: Truffot, Aurélie, Andréani, Julien, Le Maréchal, Marion, Caporossi, Alban, Epaulard, Olivier, Germi, Raphaele, Poignard, Pascal, Larrat, Sylvie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2021
Materias:
Research Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8462331/
https://www.ncbi.nlm.nih.gov/pubmed/34352197
http://dx.doi.org/10.3201/eid2710.211509
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author Truffot, Aurélie
Andréani, Julien
Le Maréchal, Marion
Caporossi, Alban
Epaulard, Olivier
Germi, Raphaele
Poignard, Pascal
Larrat, Sylvie
author_facet Truffot, Aurélie
Andréani, Julien
Le Maréchal, Marion
Caporossi, Alban
Epaulard, Olivier
Germi, Raphaele
Poignard, Pascal
Larrat, Sylvie
author_sort Truffot, Aurélie
collection PubMed
description A 72-year-old immunocompromised man infected with severe acute respiratory syndrome coronavirus 2 received bamlanivimab monotherapy. Viral evolution was monitored in nasopharyngeal and blood samples by melting curve analysis of single-nucleotide polymorphisms and whole-genome sequencing. Rapid emergence of spike receptor binding domain mutations was found, associated with a compartmentalization of viral populations.
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spelling pubmed-84623312021-10-07 SARS-CoV-2 Variants in Immunocompromised Patient Given Antibody Monotherapy Truffot, Aurélie Andréani, Julien Le Maréchal, Marion Caporossi, Alban Epaulard, Olivier Germi, Raphaele Poignard, Pascal Larrat, Sylvie Emerg Infect Dis Research Letter A 72-year-old immunocompromised man infected with severe acute respiratory syndrome coronavirus 2 received bamlanivimab monotherapy. Viral evolution was monitored in nasopharyngeal and blood samples by melting curve analysis of single-nucleotide polymorphisms and whole-genome sequencing. Rapid emergence of spike receptor binding domain mutations was found, associated with a compartmentalization of viral populations. Centers for Disease Control and Prevention 2021-10 /pmc/articles/PMC8462331/ /pubmed/34352197 http://dx.doi.org/10.3201/eid2710.211509 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Research Letter
Truffot, Aurélie
Andréani, Julien
Le Maréchal, Marion
Caporossi, Alban
Epaulard, Olivier
Germi, Raphaele
Poignard, Pascal
Larrat, Sylvie
SARS-CoV-2 Variants in Immunocompromised Patient Given Antibody Monotherapy
title SARS-CoV-2 Variants in Immunocompromised Patient Given Antibody Monotherapy
title_full SARS-CoV-2 Variants in Immunocompromised Patient Given Antibody Monotherapy
title_fullStr SARS-CoV-2 Variants in Immunocompromised Patient Given Antibody Monotherapy
title_full_unstemmed SARS-CoV-2 Variants in Immunocompromised Patient Given Antibody Monotherapy
title_short SARS-CoV-2 Variants in Immunocompromised Patient Given Antibody Monotherapy
title_sort sars-cov-2 variants in immunocompromised patient given antibody monotherapy
topic Research Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8462331/
https://www.ncbi.nlm.nih.gov/pubmed/34352197
http://dx.doi.org/10.3201/eid2710.211509
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