Emergence of SARS-COV-2 Spike Protein Escape Mutation Q493R after Treatment for COVID-19

We report in vivo selection of a severe acute respiratory syndrome coronavirus 2 spike mutation (Q493R) conferring simultaneous resistance to bamlanivimab and etesivimab. This mutation was isolated from a patient who had coronavirus disease and was treated with these drugs.

Detalles Bibliográficos
Autores principales: Focosi, Daniele, Novazzi, Federica, Genoni, Angelo, Dentali, Francesco, Gasperina, Daniela Dalla, Baj, Andreina, Maggi, Fabrizio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2021
Materias:
Research Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8462334/
https://www.ncbi.nlm.nih.gov/pubmed/34314668
http://dx.doi.org/10.3201/eid2710.211538
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author Focosi, Daniele
Novazzi, Federica
Genoni, Angelo
Dentali, Francesco
Gasperina, Daniela Dalla
Baj, Andreina
Maggi, Fabrizio
author_facet Focosi, Daniele
Novazzi, Federica
Genoni, Angelo
Dentali, Francesco
Gasperina, Daniela Dalla
Baj, Andreina
Maggi, Fabrizio
author_sort Focosi, Daniele
collection PubMed
description We report in vivo selection of a severe acute respiratory syndrome coronavirus 2 spike mutation (Q493R) conferring simultaneous resistance to bamlanivimab and etesivimab. This mutation was isolated from a patient who had coronavirus disease and was treated with these drugs.
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spelling pubmed-84623342021-10-07 Emergence of SARS-COV-2 Spike Protein Escape Mutation Q493R after Treatment for COVID-19 Focosi, Daniele Novazzi, Federica Genoni, Angelo Dentali, Francesco Gasperina, Daniela Dalla Baj, Andreina Maggi, Fabrizio Emerg Infect Dis Research Letter We report in vivo selection of a severe acute respiratory syndrome coronavirus 2 spike mutation (Q493R) conferring simultaneous resistance to bamlanivimab and etesivimab. This mutation was isolated from a patient who had coronavirus disease and was treated with these drugs. Centers for Disease Control and Prevention 2021-10 /pmc/articles/PMC8462334/ /pubmed/34314668 http://dx.doi.org/10.3201/eid2710.211538 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Research Letter
Focosi, Daniele
Novazzi, Federica
Genoni, Angelo
Dentali, Francesco
Gasperina, Daniela Dalla
Baj, Andreina
Maggi, Fabrizio
Emergence of SARS-COV-2 Spike Protein Escape Mutation Q493R after Treatment for COVID-19
title Emergence of SARS-COV-2 Spike Protein Escape Mutation Q493R after Treatment for COVID-19
title_full Emergence of SARS-COV-2 Spike Protein Escape Mutation Q493R after Treatment for COVID-19
title_fullStr Emergence of SARS-COV-2 Spike Protein Escape Mutation Q493R after Treatment for COVID-19
title_full_unstemmed Emergence of SARS-COV-2 Spike Protein Escape Mutation Q493R after Treatment for COVID-19
title_short Emergence of SARS-COV-2 Spike Protein Escape Mutation Q493R after Treatment for COVID-19
title_sort emergence of sars-cov-2 spike protein escape mutation q493r after treatment for covid-19
topic Research Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8462334/
https://www.ncbi.nlm.nih.gov/pubmed/34314668
http://dx.doi.org/10.3201/eid2710.211538
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