Therapeutic Efficacy of Human Monoclonal Antibodies against Andes Virus Infection in Syrian Hamsters

Andes virus, an orthohantavirus endemic to South America, causes severe hantavirus cardiopulmonary syndrome associated with human-to-human transmission. No approved treatments or vaccines against this virus are available. We show that a combined treatment with 2 monoclonal antibodies protected Syria...

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Autores principales: Williamson, Brandi N., Prescott, Joseph, Garrido, Jose L., Alvarez, Raymond A., Feldmann, Heinz, Barría, Maria I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2021
Materias:
Dispatch
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8462347/
https://www.ncbi.nlm.nih.gov/pubmed/34545791
http://dx.doi.org/10.3201/eid2710.210735
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author Williamson, Brandi N.
Prescott, Joseph
Garrido, Jose L.
Alvarez, Raymond A.
Feldmann, Heinz
Barría, Maria I.
author_facet Williamson, Brandi N.
Prescott, Joseph
Garrido, Jose L.
Alvarez, Raymond A.
Feldmann, Heinz
Barría, Maria I.
author_sort Williamson, Brandi N.
collection PubMed
description Andes virus, an orthohantavirus endemic to South America, causes severe hantavirus cardiopulmonary syndrome associated with human-to-human transmission. No approved treatments or vaccines against this virus are available. We show that a combined treatment with 2 monoclonal antibodies protected Syrian hamsters when administered at midstage or late-stage disease.
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spelling pubmed-84623472021-10-07 Therapeutic Efficacy of Human Monoclonal Antibodies against Andes Virus Infection in Syrian Hamsters Williamson, Brandi N. Prescott, Joseph Garrido, Jose L. Alvarez, Raymond A. Feldmann, Heinz Barría, Maria I. Emerg Infect Dis Dispatch Andes virus, an orthohantavirus endemic to South America, causes severe hantavirus cardiopulmonary syndrome associated with human-to-human transmission. No approved treatments or vaccines against this virus are available. We show that a combined treatment with 2 monoclonal antibodies protected Syrian hamsters when administered at midstage or late-stage disease. Centers for Disease Control and Prevention 2021-10 /pmc/articles/PMC8462347/ /pubmed/34545791 http://dx.doi.org/10.3201/eid2710.210735 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Dispatch
Williamson, Brandi N.
Prescott, Joseph
Garrido, Jose L.
Alvarez, Raymond A.
Feldmann, Heinz
Barría, Maria I.
Therapeutic Efficacy of Human Monoclonal Antibodies against Andes Virus Infection in Syrian Hamsters
title Therapeutic Efficacy of Human Monoclonal Antibodies against Andes Virus Infection in Syrian Hamsters
title_full Therapeutic Efficacy of Human Monoclonal Antibodies against Andes Virus Infection in Syrian Hamsters
title_fullStr Therapeutic Efficacy of Human Monoclonal Antibodies against Andes Virus Infection in Syrian Hamsters
title_full_unstemmed Therapeutic Efficacy of Human Monoclonal Antibodies against Andes Virus Infection in Syrian Hamsters
title_short Therapeutic Efficacy of Human Monoclonal Antibodies against Andes Virus Infection in Syrian Hamsters
title_sort therapeutic efficacy of human monoclonal antibodies against andes virus infection in syrian hamsters
topic Dispatch
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8462347/
https://www.ncbi.nlm.nih.gov/pubmed/34545791
http://dx.doi.org/10.3201/eid2710.210735
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