Fentanyl-Induced Respiratory Depression: A Narrative Review on the Possible Single-Nucleotide Polymorphism

Opioid-related respiratory depression is a serious clinical problem as it can cause multiple deaths and anoxic brain injury. Genetic variations influence the safety and clinical efficacy of fentanyl. Pharmacogenetic studies help in identifying single-nucleotide polymorphisms (SNPs) associated with f...

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Detalles Bibliográficos
Autores principales: Udayakumar, Prabha, Udayakumar, Srisruthi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2021
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8462425/
https://www.ncbi.nlm.nih.gov/pubmed/34667340
http://dx.doi.org/10.4103/aer.aer_94_21
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author Udayakumar, Prabha
Udayakumar, Srisruthi
author_facet Udayakumar, Prabha
Udayakumar, Srisruthi
author_sort Udayakumar, Prabha
collection PubMed
description Opioid-related respiratory depression is a serious clinical problem as it can cause multiple deaths and anoxic brain injury. Genetic variations influence the safety and clinical efficacy of fentanyl. Pharmacogenetic studies help in identifying single-nucleotide polymorphisms (SNPs) associated with fentanyl causing respiratory depression and aid clinician in personalized pain medicine. This narrative review gives an insight of the common SNPs associated with fentanyl.
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spelling pubmed-84624252021-10-18 Fentanyl-Induced Respiratory Depression: A Narrative Review on the Possible Single-Nucleotide Polymorphism Udayakumar, Prabha Udayakumar, Srisruthi Anesth Essays Res Review Article Opioid-related respiratory depression is a serious clinical problem as it can cause multiple deaths and anoxic brain injury. Genetic variations influence the safety and clinical efficacy of fentanyl. Pharmacogenetic studies help in identifying single-nucleotide polymorphisms (SNPs) associated with fentanyl causing respiratory depression and aid clinician in personalized pain medicine. This narrative review gives an insight of the common SNPs associated with fentanyl. Wolters Kluwer - Medknow 2021 2021-08-30 /pmc/articles/PMC8462425/ /pubmed/34667340 http://dx.doi.org/10.4103/aer.aer_94_21 Text en Copyright: © 2021 Anesthesia: Essays and Researches https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Review Article
Udayakumar, Prabha
Udayakumar, Srisruthi
Fentanyl-Induced Respiratory Depression: A Narrative Review on the Possible Single-Nucleotide Polymorphism
title Fentanyl-Induced Respiratory Depression: A Narrative Review on the Possible Single-Nucleotide Polymorphism
title_full Fentanyl-Induced Respiratory Depression: A Narrative Review on the Possible Single-Nucleotide Polymorphism
title_fullStr Fentanyl-Induced Respiratory Depression: A Narrative Review on the Possible Single-Nucleotide Polymorphism
title_full_unstemmed Fentanyl-Induced Respiratory Depression: A Narrative Review on the Possible Single-Nucleotide Polymorphism
title_short Fentanyl-Induced Respiratory Depression: A Narrative Review on the Possible Single-Nucleotide Polymorphism
title_sort fentanyl-induced respiratory depression: a narrative review on the possible single-nucleotide polymorphism
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8462425/
https://www.ncbi.nlm.nih.gov/pubmed/34667340
http://dx.doi.org/10.4103/aer.aer_94_21
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