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Traditional Chinese medicine for septic patients undergoing ulinastatin therapy: A meta-analysis

PURPOSE: This study aimed to assess the efficacy of traditional Chinese medicine (TCM) in septic patients treated with ulinastatin. METHODS: PubMed, EmBase, and the Cochrane library were searched up to January 2021 to identify randomized controlled trials. The weight mean difference (WMD) and relati...

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Autores principales: Shan, Ren-Fei, Zhu, Yan-An, Qin, Jie, Chen, Jian-Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8462559/
https://www.ncbi.nlm.nih.gov/pubmed/34559104
http://dx.doi.org/10.1097/MD.0000000000027151
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author Shan, Ren-Fei
Zhu, Yan-An
Qin, Jie
Chen, Jian-Ping
author_facet Shan, Ren-Fei
Zhu, Yan-An
Qin, Jie
Chen, Jian-Ping
author_sort Shan, Ren-Fei
collection PubMed
description PURPOSE: This study aimed to assess the efficacy of traditional Chinese medicine (TCM) in septic patients treated with ulinastatin. METHODS: PubMed, EmBase, and the Cochrane library were searched up to January 2021 to identify randomized controlled trials. The weight mean difference (WMD) and relative risk (RR) with 95% confidence intervals were used with the random-effects model. RESULTS: Twenty-three randomized controlled trials with 1903 septic patients were included. TCM significantly reduced the APACHE II score (WMD: −5.18; P < .001), interleukin-6 (WMD: −63.00; P < .001), tumor necrosis factor-α (WMD: −8.86; P < .001), c-reactive protein (WMD: −9.47; P < .001), mechanical ventilation duration (WMD: −3.98; P < .001), intensive care unit stay (WMD: −4.18; P < .001), procalcitonin (WMD: −0.53; P < .001), lipopolysaccharide (WMD: −9.69; P < .001), B-type natriuretic peptide (WMD: −159.87; P < .001), creatine kinase isoenzyme MB (WMD: −45.67; P < .001), cardiac troponin I (WMD: −0.66; P < .001), and all-cause mortality risk (RR: 0.55; P < .001). CONCLUSIONS: TCM lowers inflammation levels and reduces the risk of all-cause mortality for septic patients.
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spelling pubmed-84625592021-09-27 Traditional Chinese medicine for septic patients undergoing ulinastatin therapy: A meta-analysis Shan, Ren-Fei Zhu, Yan-An Qin, Jie Chen, Jian-Ping Medicine (Baltimore) 3800 PURPOSE: This study aimed to assess the efficacy of traditional Chinese medicine (TCM) in septic patients treated with ulinastatin. METHODS: PubMed, EmBase, and the Cochrane library were searched up to January 2021 to identify randomized controlled trials. The weight mean difference (WMD) and relative risk (RR) with 95% confidence intervals were used with the random-effects model. RESULTS: Twenty-three randomized controlled trials with 1903 septic patients were included. TCM significantly reduced the APACHE II score (WMD: −5.18; P < .001), interleukin-6 (WMD: −63.00; P < .001), tumor necrosis factor-α (WMD: −8.86; P < .001), c-reactive protein (WMD: −9.47; P < .001), mechanical ventilation duration (WMD: −3.98; P < .001), intensive care unit stay (WMD: −4.18; P < .001), procalcitonin (WMD: −0.53; P < .001), lipopolysaccharide (WMD: −9.69; P < .001), B-type natriuretic peptide (WMD: −159.87; P < .001), creatine kinase isoenzyme MB (WMD: −45.67; P < .001), cardiac troponin I (WMD: −0.66; P < .001), and all-cause mortality risk (RR: 0.55; P < .001). CONCLUSIONS: TCM lowers inflammation levels and reduces the risk of all-cause mortality for septic patients. Lippincott Williams & Wilkins 2021-09-24 /pmc/articles/PMC8462559/ /pubmed/34559104 http://dx.doi.org/10.1097/MD.0000000000027151 Text en Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/)
spellingShingle 3800
Shan, Ren-Fei
Zhu, Yan-An
Qin, Jie
Chen, Jian-Ping
Traditional Chinese medicine for septic patients undergoing ulinastatin therapy: A meta-analysis
title Traditional Chinese medicine for septic patients undergoing ulinastatin therapy: A meta-analysis
title_full Traditional Chinese medicine for septic patients undergoing ulinastatin therapy: A meta-analysis
title_fullStr Traditional Chinese medicine for septic patients undergoing ulinastatin therapy: A meta-analysis
title_full_unstemmed Traditional Chinese medicine for septic patients undergoing ulinastatin therapy: A meta-analysis
title_short Traditional Chinese medicine for septic patients undergoing ulinastatin therapy: A meta-analysis
title_sort traditional chinese medicine for septic patients undergoing ulinastatin therapy: a meta-analysis
topic 3800
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8462559/
https://www.ncbi.nlm.nih.gov/pubmed/34559104
http://dx.doi.org/10.1097/MD.0000000000027151
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