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Traditional Chinese medicine for septic patients undergoing ulinastatin therapy: A meta-analysis
PURPOSE: This study aimed to assess the efficacy of traditional Chinese medicine (TCM) in septic patients treated with ulinastatin. METHODS: PubMed, EmBase, and the Cochrane library were searched up to January 2021 to identify randomized controlled trials. The weight mean difference (WMD) and relati...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8462559/ https://www.ncbi.nlm.nih.gov/pubmed/34559104 http://dx.doi.org/10.1097/MD.0000000000027151 |
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author | Shan, Ren-Fei Zhu, Yan-An Qin, Jie Chen, Jian-Ping |
author_facet | Shan, Ren-Fei Zhu, Yan-An Qin, Jie Chen, Jian-Ping |
author_sort | Shan, Ren-Fei |
collection | PubMed |
description | PURPOSE: This study aimed to assess the efficacy of traditional Chinese medicine (TCM) in septic patients treated with ulinastatin. METHODS: PubMed, EmBase, and the Cochrane library were searched up to January 2021 to identify randomized controlled trials. The weight mean difference (WMD) and relative risk (RR) with 95% confidence intervals were used with the random-effects model. RESULTS: Twenty-three randomized controlled trials with 1903 septic patients were included. TCM significantly reduced the APACHE II score (WMD: −5.18; P < .001), interleukin-6 (WMD: −63.00; P < .001), tumor necrosis factor-α (WMD: −8.86; P < .001), c-reactive protein (WMD: −9.47; P < .001), mechanical ventilation duration (WMD: −3.98; P < .001), intensive care unit stay (WMD: −4.18; P < .001), procalcitonin (WMD: −0.53; P < .001), lipopolysaccharide (WMD: −9.69; P < .001), B-type natriuretic peptide (WMD: −159.87; P < .001), creatine kinase isoenzyme MB (WMD: −45.67; P < .001), cardiac troponin I (WMD: −0.66; P < .001), and all-cause mortality risk (RR: 0.55; P < .001). CONCLUSIONS: TCM lowers inflammation levels and reduces the risk of all-cause mortality for septic patients. |
format | Online Article Text |
id | pubmed-8462559 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-84625592021-09-27 Traditional Chinese medicine for septic patients undergoing ulinastatin therapy: A meta-analysis Shan, Ren-Fei Zhu, Yan-An Qin, Jie Chen, Jian-Ping Medicine (Baltimore) 3800 PURPOSE: This study aimed to assess the efficacy of traditional Chinese medicine (TCM) in septic patients treated with ulinastatin. METHODS: PubMed, EmBase, and the Cochrane library were searched up to January 2021 to identify randomized controlled trials. The weight mean difference (WMD) and relative risk (RR) with 95% confidence intervals were used with the random-effects model. RESULTS: Twenty-three randomized controlled trials with 1903 septic patients were included. TCM significantly reduced the APACHE II score (WMD: −5.18; P < .001), interleukin-6 (WMD: −63.00; P < .001), tumor necrosis factor-α (WMD: −8.86; P < .001), c-reactive protein (WMD: −9.47; P < .001), mechanical ventilation duration (WMD: −3.98; P < .001), intensive care unit stay (WMD: −4.18; P < .001), procalcitonin (WMD: −0.53; P < .001), lipopolysaccharide (WMD: −9.69; P < .001), B-type natriuretic peptide (WMD: −159.87; P < .001), creatine kinase isoenzyme MB (WMD: −45.67; P < .001), cardiac troponin I (WMD: −0.66; P < .001), and all-cause mortality risk (RR: 0.55; P < .001). CONCLUSIONS: TCM lowers inflammation levels and reduces the risk of all-cause mortality for septic patients. Lippincott Williams & Wilkins 2021-09-24 /pmc/articles/PMC8462559/ /pubmed/34559104 http://dx.doi.org/10.1097/MD.0000000000027151 Text en Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) |
spellingShingle | 3800 Shan, Ren-Fei Zhu, Yan-An Qin, Jie Chen, Jian-Ping Traditional Chinese medicine for septic patients undergoing ulinastatin therapy: A meta-analysis |
title | Traditional Chinese medicine for septic patients undergoing ulinastatin therapy: A meta-analysis |
title_full | Traditional Chinese medicine for septic patients undergoing ulinastatin therapy: A meta-analysis |
title_fullStr | Traditional Chinese medicine for septic patients undergoing ulinastatin therapy: A meta-analysis |
title_full_unstemmed | Traditional Chinese medicine for septic patients undergoing ulinastatin therapy: A meta-analysis |
title_short | Traditional Chinese medicine for septic patients undergoing ulinastatin therapy: A meta-analysis |
title_sort | traditional chinese medicine for septic patients undergoing ulinastatin therapy: a meta-analysis |
topic | 3800 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8462559/ https://www.ncbi.nlm.nih.gov/pubmed/34559104 http://dx.doi.org/10.1097/MD.0000000000027151 |
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