Topoisomerase I inhibition and peripheral nerve injury induce DNA breaks and ATF3-associated axon regeneration in sensory neurons

Although axonal damage induces rapid changes in gene expression in primary sensory neurons, it remains unclear how this process is initiated. The transcription factor ATF3, one of the earliest genes responding to nerve injury, regulates expression of downstream genes that enable axon regeneration. B...

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Detalles Bibliográficos
Autores principales: Cheng, Yung-Chih, Snavely, Andrew, Barrett, Lee B., Zhang, Xuefei, Herman, Crystal, Frost, Devlin J., Riva, Priscilla, Tochitsky, Ivan, Kawaguchi, Riki, Singh, Bhagat, Ivanis, Jelena, Huebner, Eric A., Arvanites, Anthony, Oza, Vatsal, Davidow, Lance, Maeda, Rie, Sakuma, Miyuki, Grantham, Alyssa, Wang, Qing, Chang, Amelia N., Pfaff, Kathleen, Costigan, Michael, Coppola, Giovanni, Rubin, Lee L., Schwer, Bjoern, Alt, Frederick W., Woolf, Clifford J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8462619/
https://www.ncbi.nlm.nih.gov/pubmed/34496254
http://dx.doi.org/10.1016/j.celrep.2021.109666

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