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Chinese herbal medicine for mild cognitive impairment using mini-mental state examination: A systematic review and meta-analysis

INTRODUCTION: The prevalence of mild cognitive impairment (MCI) in the elderly population aged 60 to 84 years ranges from 6.7% to 25.2%, and the effective prevention and reversal of MCI progression to Alzheimer disease (AD) is crucial. The mini mental state examination (MMSE) is the most commonly us...

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Autores principales: Wang, Wei, Diwu, Yongchang, Liu, Qi, Zhou, Yuan, Sayed, Tayeb Islam, Wang, Dongkun, Gou, Yurui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8462642/
https://www.ncbi.nlm.nih.gov/pubmed/34559097
http://dx.doi.org/10.1097/MD.0000000000027034
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author Wang, Wei
Diwu, Yongchang
Liu, Qi
Zhou, Yuan
Sayed, Tayeb Islam
Wang, Dongkun
Gou, Yurui
author_facet Wang, Wei
Diwu, Yongchang
Liu, Qi
Zhou, Yuan
Sayed, Tayeb Islam
Wang, Dongkun
Gou, Yurui
author_sort Wang, Wei
collection PubMed
description INTRODUCTION: The prevalence of mild cognitive impairment (MCI) in the elderly population aged 60 to 84 years ranges from 6.7% to 25.2%, and the effective prevention and reversal of MCI progression to Alzheimer disease (AD) is crucial. The mini mental state examination (MMSE) is the most commonly used screening tool in Chinese outpatient clinics, with sufficient sensitivity and specificity to allow useful stratification from average to abnormal with adequate consideration of age and education. OBJECTIVE: To investigate the clinical significance of Chinese herbs on MMSE scores in MCI patients and discuss the effectiveness of Chinese herbs through pharmacology. METHODS: Three English databases and 4 Chinese databases we have searched, and the risk of bias was assessed according to the Cochrane tool. Statistics will be used for heterogeneity assessment, sensitivity analysis, data synthesis, funnel plot generation and subgroup analysis. If sufficiently homogeneous studies are found, a Meta-analysis will be performed, with subgroups describing any differences. RESULTS: A total of 21 studies were included, 4 studies were placebo-controlled, 14 Chinese Herbal Medicines (CHMs) were compared with other cognitive improvements, 3 CHMs were combined with other medications, and the results of 17 studies favored the herbal group. CONCLUSION: The results indicate that herbal medicine can improve MMSE scores, and herbal medicine combined with other drugs that can improve cognition can significantly improve MMSE scores, but there are methodological flaws in the study. Experimental studies have found a basis for the ability of herbs to improve cognition and memory impairment, and herbal medicine has great potential to improve MCI cognition. Keywords mild cognitive impairment, herbal medicine, MMSE, systematic evaluation, meta-analysis. PROSPERO international prospective register of systematic reviews protocol registration number: CRD42020202368
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spelling pubmed-84626422021-09-27 Chinese herbal medicine for mild cognitive impairment using mini-mental state examination: A systematic review and meta-analysis Wang, Wei Diwu, Yongchang Liu, Qi Zhou, Yuan Sayed, Tayeb Islam Wang, Dongkun Gou, Yurui Medicine (Baltimore) 3800 INTRODUCTION: The prevalence of mild cognitive impairment (MCI) in the elderly population aged 60 to 84 years ranges from 6.7% to 25.2%, and the effective prevention and reversal of MCI progression to Alzheimer disease (AD) is crucial. The mini mental state examination (MMSE) is the most commonly used screening tool in Chinese outpatient clinics, with sufficient sensitivity and specificity to allow useful stratification from average to abnormal with adequate consideration of age and education. OBJECTIVE: To investigate the clinical significance of Chinese herbs on MMSE scores in MCI patients and discuss the effectiveness of Chinese herbs through pharmacology. METHODS: Three English databases and 4 Chinese databases we have searched, and the risk of bias was assessed according to the Cochrane tool. Statistics will be used for heterogeneity assessment, sensitivity analysis, data synthesis, funnel plot generation and subgroup analysis. If sufficiently homogeneous studies are found, a Meta-analysis will be performed, with subgroups describing any differences. RESULTS: A total of 21 studies were included, 4 studies were placebo-controlled, 14 Chinese Herbal Medicines (CHMs) were compared with other cognitive improvements, 3 CHMs were combined with other medications, and the results of 17 studies favored the herbal group. CONCLUSION: The results indicate that herbal medicine can improve MMSE scores, and herbal medicine combined with other drugs that can improve cognition can significantly improve MMSE scores, but there are methodological flaws in the study. Experimental studies have found a basis for the ability of herbs to improve cognition and memory impairment, and herbal medicine has great potential to improve MCI cognition. Keywords mild cognitive impairment, herbal medicine, MMSE, systematic evaluation, meta-analysis. PROSPERO international prospective register of systematic reviews protocol registration number: CRD42020202368 Lippincott Williams & Wilkins 2021-09-24 /pmc/articles/PMC8462642/ /pubmed/34559097 http://dx.doi.org/10.1097/MD.0000000000027034 Text en Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/)
spellingShingle 3800
Wang, Wei
Diwu, Yongchang
Liu, Qi
Zhou, Yuan
Sayed, Tayeb Islam
Wang, Dongkun
Gou, Yurui
Chinese herbal medicine for mild cognitive impairment using mini-mental state examination: A systematic review and meta-analysis
title Chinese herbal medicine for mild cognitive impairment using mini-mental state examination: A systematic review and meta-analysis
title_full Chinese herbal medicine for mild cognitive impairment using mini-mental state examination: A systematic review and meta-analysis
title_fullStr Chinese herbal medicine for mild cognitive impairment using mini-mental state examination: A systematic review and meta-analysis
title_full_unstemmed Chinese herbal medicine for mild cognitive impairment using mini-mental state examination: A systematic review and meta-analysis
title_short Chinese herbal medicine for mild cognitive impairment using mini-mental state examination: A systematic review and meta-analysis
title_sort chinese herbal medicine for mild cognitive impairment using mini-mental state examination: a systematic review and meta-analysis
topic 3800
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8462642/
https://www.ncbi.nlm.nih.gov/pubmed/34559097
http://dx.doi.org/10.1097/MD.0000000000027034
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