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Biosafety of a novel covered self-expandable metal stent coated with poly(2-methoxyethyl acrylate) in vivo

Covered self-expandable metal stents (CSEMS) are often used for palliative endoscopic biliary drainage; however, the unobstructed period is limited because of sludge occlusion. The present study aimed to evaluate the biosafety of a novel poly(2-methoxyethyl acrylate)-coated CSEMS (PMEA-CSEMS) for sl...

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Autores principales: Ishizawa, Tetsuya, Makino, Naohiko, Kakizaki, Yasuharu, Matsuda, Akiko, Toyokawa, Yoshihide, Ooyama, Shun, Tanaka, Masaru, Ueno, Yoshiyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8462702/
https://www.ncbi.nlm.nih.gov/pubmed/34559849
http://dx.doi.org/10.1371/journal.pone.0257828
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author Ishizawa, Tetsuya
Makino, Naohiko
Kakizaki, Yasuharu
Matsuda, Akiko
Toyokawa, Yoshihide
Ooyama, Shun
Tanaka, Masaru
Ueno, Yoshiyuki
author_facet Ishizawa, Tetsuya
Makino, Naohiko
Kakizaki, Yasuharu
Matsuda, Akiko
Toyokawa, Yoshihide
Ooyama, Shun
Tanaka, Masaru
Ueno, Yoshiyuki
author_sort Ishizawa, Tetsuya
collection PubMed
description Covered self-expandable metal stents (CSEMS) are often used for palliative endoscopic biliary drainage; however, the unobstructed period is limited because of sludge occlusion. The present study aimed to evaluate the biosafety of a novel poly(2-methoxyethyl acrylate)-coated CSEMS (PMEA-CSEMS) for sludge resistance and examine its biosafety in vivo. Using endoscopic retrograde cholangiopancreatography, we placed the PMEA-CSEMS into six normal porcine bile ducts and conventional CSEMS into three normal porcine bile ducts. We performed serological examination and undecalcified histological analysis at 1, 3, and 6 months during follow-up. In the bile ducts with PMEA-CSEMS or conventional CSEMS, we observed no increase in liver enzyme or inflammatory marker levels in the serological investigations and mild fibrosis but no inflammatory response in the histopathological analyses. Thus, we demonstrated the biosafety of PMEA-CSEMS in vivo.
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spelling pubmed-84627022021-09-25 Biosafety of a novel covered self-expandable metal stent coated with poly(2-methoxyethyl acrylate) in vivo Ishizawa, Tetsuya Makino, Naohiko Kakizaki, Yasuharu Matsuda, Akiko Toyokawa, Yoshihide Ooyama, Shun Tanaka, Masaru Ueno, Yoshiyuki PLoS One Research Article Covered self-expandable metal stents (CSEMS) are often used for palliative endoscopic biliary drainage; however, the unobstructed period is limited because of sludge occlusion. The present study aimed to evaluate the biosafety of a novel poly(2-methoxyethyl acrylate)-coated CSEMS (PMEA-CSEMS) for sludge resistance and examine its biosafety in vivo. Using endoscopic retrograde cholangiopancreatography, we placed the PMEA-CSEMS into six normal porcine bile ducts and conventional CSEMS into three normal porcine bile ducts. We performed serological examination and undecalcified histological analysis at 1, 3, and 6 months during follow-up. In the bile ducts with PMEA-CSEMS or conventional CSEMS, we observed no increase in liver enzyme or inflammatory marker levels in the serological investigations and mild fibrosis but no inflammatory response in the histopathological analyses. Thus, we demonstrated the biosafety of PMEA-CSEMS in vivo. Public Library of Science 2021-09-24 /pmc/articles/PMC8462702/ /pubmed/34559849 http://dx.doi.org/10.1371/journal.pone.0257828 Text en © 2021 Ishizawa et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Ishizawa, Tetsuya
Makino, Naohiko
Kakizaki, Yasuharu
Matsuda, Akiko
Toyokawa, Yoshihide
Ooyama, Shun
Tanaka, Masaru
Ueno, Yoshiyuki
Biosafety of a novel covered self-expandable metal stent coated with poly(2-methoxyethyl acrylate) in vivo
title Biosafety of a novel covered self-expandable metal stent coated with poly(2-methoxyethyl acrylate) in vivo
title_full Biosafety of a novel covered self-expandable metal stent coated with poly(2-methoxyethyl acrylate) in vivo
title_fullStr Biosafety of a novel covered self-expandable metal stent coated with poly(2-methoxyethyl acrylate) in vivo
title_full_unstemmed Biosafety of a novel covered self-expandable metal stent coated with poly(2-methoxyethyl acrylate) in vivo
title_short Biosafety of a novel covered self-expandable metal stent coated with poly(2-methoxyethyl acrylate) in vivo
title_sort biosafety of a novel covered self-expandable metal stent coated with poly(2-methoxyethyl acrylate) in vivo
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8462702/
https://www.ncbi.nlm.nih.gov/pubmed/34559849
http://dx.doi.org/10.1371/journal.pone.0257828
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