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Elevated serum galectin-1 concentrations are associated with increased risks of mortality and acute kidney injury in critically ill patients

BACKGROUND: Galectin-1 (Gal-1), a member of the β-galactoside binding protein family, is associated with inflammation and chronic kidney disease. However, the effect of Gal-1 on mortality and acute kidney injury (AKI) in critically-ill patients remain unclear. METHODS: From May 2018 to March 2020, 3...

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Autores principales: Chou, Ruey-Hsing, Tsai, Chuan-Tsai, Lu, Ya-Wen, Guo, Jiun-Yu, Lu, Chi-Ting, Tsai, Yi-Lin, Wu, Cheng-Hsueh, Lin, Shing-Jong, Lien, Ru-Yu, Lu, Shu-Fen, Yang, Shang-Feng, Huang, Po-Hsun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8462742/
https://www.ncbi.nlm.nih.gov/pubmed/34559847
http://dx.doi.org/10.1371/journal.pone.0257558
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author Chou, Ruey-Hsing
Tsai, Chuan-Tsai
Lu, Ya-Wen
Guo, Jiun-Yu
Lu, Chi-Ting
Tsai, Yi-Lin
Wu, Cheng-Hsueh
Lin, Shing-Jong
Lien, Ru-Yu
Lu, Shu-Fen
Yang, Shang-Feng
Huang, Po-Hsun
author_facet Chou, Ruey-Hsing
Tsai, Chuan-Tsai
Lu, Ya-Wen
Guo, Jiun-Yu
Lu, Chi-Ting
Tsai, Yi-Lin
Wu, Cheng-Hsueh
Lin, Shing-Jong
Lien, Ru-Yu
Lu, Shu-Fen
Yang, Shang-Feng
Huang, Po-Hsun
author_sort Chou, Ruey-Hsing
collection PubMed
description BACKGROUND: Galectin-1 (Gal-1), a member of the β-galactoside binding protein family, is associated with inflammation and chronic kidney disease. However, the effect of Gal-1 on mortality and acute kidney injury (AKI) in critically-ill patients remain unclear. METHODS: From May 2018 to March 2020, 350 patients admitted to the medical intensive care unit (ICU) of Taipei Veterans General Hospital, a tertiary medical center, were enrolled in this study. Forty-one patients receiving long-term renal replacement therapy were excluded. Serum Gal-1 levels were determined within 24 h of ICU admission. The patients were divided into tertiles according to their serum Gal-1 levels (low, serum Gal-1 < 39 ng/ml; median, 39–70 ng/ml; high, ≥71 ng/ml). All patients were followed for 90 days or until death. RESULTS: Mortality in the ICU and at 90 days was greater among patients with elevated serum Gal-1 levels. In analyses adjusted for the body mass index, malignancy, sepsis, Sequential Organ Failure Assessment (SOFA) score, and serum lactate level, the serum Gal-1 level remained an independent predictor of 90-day mortality [median vs. low: adjusted hazard ratio (aHR) 2.11, 95% confidence interval (CI) 1.24–3.60, p = 0.006; high vs. low: aHR 3.21, 95% CI 1.90–5.42, p < 0.001]. Higher serum Gal-1 levels were also associated with a higher incidence of AKI within 48 h after ICU admission, independent of the SOFA score and renal function (median vs. low: aHR 2.77, 95% CI 1.21–6.34, p = 0.016; high vs. low: aHR 2.88, 95% CI 1.20–6.88, p = 0.017). The results were consistent among different subgroups with high and low Gal-1 levels. CONCLUSION: Serum Gal-1 elevation at the time of ICU admission were associated with an increased risk of mortality at 90 days, and an increased incidence of AKI within 48 h after ICU admission.
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spelling pubmed-84627422021-09-25 Elevated serum galectin-1 concentrations are associated with increased risks of mortality and acute kidney injury in critically ill patients Chou, Ruey-Hsing Tsai, Chuan-Tsai Lu, Ya-Wen Guo, Jiun-Yu Lu, Chi-Ting Tsai, Yi-Lin Wu, Cheng-Hsueh Lin, Shing-Jong Lien, Ru-Yu Lu, Shu-Fen Yang, Shang-Feng Huang, Po-Hsun PLoS One Research Article BACKGROUND: Galectin-1 (Gal-1), a member of the β-galactoside binding protein family, is associated with inflammation and chronic kidney disease. However, the effect of Gal-1 on mortality and acute kidney injury (AKI) in critically-ill patients remain unclear. METHODS: From May 2018 to March 2020, 350 patients admitted to the medical intensive care unit (ICU) of Taipei Veterans General Hospital, a tertiary medical center, were enrolled in this study. Forty-one patients receiving long-term renal replacement therapy were excluded. Serum Gal-1 levels were determined within 24 h of ICU admission. The patients were divided into tertiles according to their serum Gal-1 levels (low, serum Gal-1 < 39 ng/ml; median, 39–70 ng/ml; high, ≥71 ng/ml). All patients were followed for 90 days or until death. RESULTS: Mortality in the ICU and at 90 days was greater among patients with elevated serum Gal-1 levels. In analyses adjusted for the body mass index, malignancy, sepsis, Sequential Organ Failure Assessment (SOFA) score, and serum lactate level, the serum Gal-1 level remained an independent predictor of 90-day mortality [median vs. low: adjusted hazard ratio (aHR) 2.11, 95% confidence interval (CI) 1.24–3.60, p = 0.006; high vs. low: aHR 3.21, 95% CI 1.90–5.42, p < 0.001]. Higher serum Gal-1 levels were also associated with a higher incidence of AKI within 48 h after ICU admission, independent of the SOFA score and renal function (median vs. low: aHR 2.77, 95% CI 1.21–6.34, p = 0.016; high vs. low: aHR 2.88, 95% CI 1.20–6.88, p = 0.017). The results were consistent among different subgroups with high and low Gal-1 levels. CONCLUSION: Serum Gal-1 elevation at the time of ICU admission were associated with an increased risk of mortality at 90 days, and an increased incidence of AKI within 48 h after ICU admission. Public Library of Science 2021-09-24 /pmc/articles/PMC8462742/ /pubmed/34559847 http://dx.doi.org/10.1371/journal.pone.0257558 Text en © 2021 Chou et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Chou, Ruey-Hsing
Tsai, Chuan-Tsai
Lu, Ya-Wen
Guo, Jiun-Yu
Lu, Chi-Ting
Tsai, Yi-Lin
Wu, Cheng-Hsueh
Lin, Shing-Jong
Lien, Ru-Yu
Lu, Shu-Fen
Yang, Shang-Feng
Huang, Po-Hsun
Elevated serum galectin-1 concentrations are associated with increased risks of mortality and acute kidney injury in critically ill patients
title Elevated serum galectin-1 concentrations are associated with increased risks of mortality and acute kidney injury in critically ill patients
title_full Elevated serum galectin-1 concentrations are associated with increased risks of mortality and acute kidney injury in critically ill patients
title_fullStr Elevated serum galectin-1 concentrations are associated with increased risks of mortality and acute kidney injury in critically ill patients
title_full_unstemmed Elevated serum galectin-1 concentrations are associated with increased risks of mortality and acute kidney injury in critically ill patients
title_short Elevated serum galectin-1 concentrations are associated with increased risks of mortality and acute kidney injury in critically ill patients
title_sort elevated serum galectin-1 concentrations are associated with increased risks of mortality and acute kidney injury in critically ill patients
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8462742/
https://www.ncbi.nlm.nih.gov/pubmed/34559847
http://dx.doi.org/10.1371/journal.pone.0257558
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