Direct administration of the non-competitive interleukin-1 receptor antagonist rytvela transiently reduced intrauterine inflammation in an extremely preterm sheep model of chorioamnionitis

BACKGROUND: Intraamniotic inflammation is associated with up to 40% of preterm births, most notably in deliveries occurring prior to 32 weeks’ gestation. Despite this, there are few treatment options allowing the prevention of preterm birth and associated fetal injury. Recent studies have shown that...

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Detalles Bibliográficos
Autores principales: Takahashi, Yuki, Saito, Masatoshi, Usuda, Haruo, Takahashi, Tsukasa, Watanabe, Shimpei, Hanita, Takushi, Sato, Shinichi, Kumagai, Yusaku, Koshinami, Shota, Ikeda, Hideyuki, Carter, Sean, Fee, Erin L., Furfaro, Lucy, Chemtob, Sylvain, Keelan, Jeffrey, Olson, David, Yaegashi, Nobuo, Newnham, John P., Jobe, Alan H., Kemp, Matthew W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8462743/
https://www.ncbi.nlm.nih.gov/pubmed/34559862
http://dx.doi.org/10.1371/journal.pone.0257847

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