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Diabetes-associated nephropathy and obesity influence COVID-19 outcome in type 2 diabetes patients
Coronavirus disease 2019 has rapidly spread around the globe and various comorbidities, such as diabetes have been recognized as risk factors for an unfavorable outcome. We analyzed a cohort of COVID-19 patients (n = 75) treated at a German community hospital. With a focus on diabetes mellitus, we e...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8462845/ https://www.ncbi.nlm.nih.gov/pubmed/34567446 http://dx.doi.org/10.1080/20009666.2021.1957555 |
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author | Schiller, Martin Solger, Kim Leipold, Stefanie Kerl, Hans Ulrich Kick, Wolfgang |
author_facet | Schiller, Martin Solger, Kim Leipold, Stefanie Kerl, Hans Ulrich Kick, Wolfgang |
author_sort | Schiller, Martin |
collection | PubMed |
description | Coronavirus disease 2019 has rapidly spread around the globe and various comorbidities, such as diabetes have been recognized as risk factors for an unfavorable outcome. We analyzed a cohort of COVID-19 patients (n = 75) treated at a German community hospital. With a focus on diabetes mellitus, we evaluated the impact of distinct comorbidities on the COVID-19 disease course. The duration of hospital stay was prolonged if diabetes was present. An older age was associated with a poor outcome. The percentage of non-survivors increased in the presence of congestive heart failure or chronic kidney disease. In the group of diabetes patients, mortality was increased if any organ complication was present and diabetic nephropathy or the combination of obesity plus diabetes were by far the most important risk factors. Taken together, an older age, congestive heart failure, and chronic kidney disease significantly influenced COVID-19 disease course and survival. Diabetic nephropathy or the combination of obesity plus diabetes had the strongest impact on patients’ outcome. |
format | Online Article Text |
id | pubmed-8462845 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-84628452021-09-25 Diabetes-associated nephropathy and obesity influence COVID-19 outcome in type 2 diabetes patients Schiller, Martin Solger, Kim Leipold, Stefanie Kerl, Hans Ulrich Kick, Wolfgang J Community Hosp Intern Med Perspect Research Article Coronavirus disease 2019 has rapidly spread around the globe and various comorbidities, such as diabetes have been recognized as risk factors for an unfavorable outcome. We analyzed a cohort of COVID-19 patients (n = 75) treated at a German community hospital. With a focus on diabetes mellitus, we evaluated the impact of distinct comorbidities on the COVID-19 disease course. The duration of hospital stay was prolonged if diabetes was present. An older age was associated with a poor outcome. The percentage of non-survivors increased in the presence of congestive heart failure or chronic kidney disease. In the group of diabetes patients, mortality was increased if any organ complication was present and diabetic nephropathy or the combination of obesity plus diabetes were by far the most important risk factors. Taken together, an older age, congestive heart failure, and chronic kidney disease significantly influenced COVID-19 disease course and survival. Diabetic nephropathy or the combination of obesity plus diabetes had the strongest impact on patients’ outcome. Taylor & Francis 2021-09-20 /pmc/articles/PMC8462845/ /pubmed/34567446 http://dx.doi.org/10.1080/20009666.2021.1957555 Text en © 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group on behalf of Greater Baltimore Medical Center. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Schiller, Martin Solger, Kim Leipold, Stefanie Kerl, Hans Ulrich Kick, Wolfgang Diabetes-associated nephropathy and obesity influence COVID-19 outcome in type 2 diabetes patients |
title | Diabetes-associated nephropathy and obesity influence COVID-19 outcome in type 2 diabetes patients |
title_full | Diabetes-associated nephropathy and obesity influence COVID-19 outcome in type 2 diabetes patients |
title_fullStr | Diabetes-associated nephropathy and obesity influence COVID-19 outcome in type 2 diabetes patients |
title_full_unstemmed | Diabetes-associated nephropathy and obesity influence COVID-19 outcome in type 2 diabetes patients |
title_short | Diabetes-associated nephropathy and obesity influence COVID-19 outcome in type 2 diabetes patients |
title_sort | diabetes-associated nephropathy and obesity influence covid-19 outcome in type 2 diabetes patients |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8462845/ https://www.ncbi.nlm.nih.gov/pubmed/34567446 http://dx.doi.org/10.1080/20009666.2021.1957555 |
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