Cargando…

Multistep mechanism of G-quadruplex resolution during DNA replication

G-quadruplex (or G4) structures form in guanine-rich DNA sequences and threaten genome stability when not properly resolved. G4 unwinding occurs during S phase via an unknown mechanism. Using Xenopus egg extracts, we define a three-step G4 unwinding mechanism that acts during DNA replication. First,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sato, Koichi, Martin-Pintado, Nerea, Post, Harm, Altelaar, Maarten, Knipscheer, Puck
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2021
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8462899/ https://www.ncbi.nlm.nih.gov/pubmed/34559566 http://dx.doi.org/10.1126/sciadv.abf8653

Ejemplares similares

RNA G-quadruplex organizes stress granule assembly through DNAPTP6 in neurons
por: Asamitsu, Sefan, et al.
Publicado: (2023)

BRCA2-HSF2BP oligomeric ring disassembly by BRME1 promotes homologous recombination
por: Ghouil, Rania, et al.
Publicado: (2023)

Multiplex enzymatic synthesis of DNA with single-base resolution
por: Verardo, Damiano, et al.
Publicado: (2023)

DNA replication initiation shapes the mutational landscape and expression of the human genome
por: Murat, Pierre, et al.
Publicado: (2022)

FIRRM/C1orf112 mediates resolution of homologous recombination intermediates in response to DNA interstrand crosslinks
por: Mazouzi, Abdelghani, et al.
Publicado: (2023)

Deficiency of replication-independent DNA mismatch repair drives a 5-methylcytosine deamination mutational signature in cancer
por: Fang, Hu, et al.
Publicado: (2021)

The linker domain of the initiator DnaA contributes to its ATP binding and membrane association in E. coli chromosomal replication
por: Hou, Yanqi, et al.
Publicado: (2022)

H3K4me3 recognition by the COMPASS complex facilitates the restoration of this histone mark following DNA replication
por: Serra-Cardona, Albert, et al.
Publicado: (2022)

Molecular architecture of the Chikungunya virus replication complex
por: Tan, Yaw Bia, et al.
Publicado: (2022)

CHK1 phosphorylates PRIMPOL to promote replication stress tolerance
por: Mehta, Kavi P. M., et al.
Publicado: (2022)

Influenza virus replication in cardiomyocytes drives heart dysfunction and fibrosis
por: Kenney, Adam D., et al.
Publicado: (2022)

FANCJ promotes DNA synthesis through G-quadruplex structures
por: Castillo Bosch, Pau, et al.
Publicado: (2014)

Comparison of replicating and nonreplicating vaccines against SARS-CoV-2
por: Mudrick, Haley E., et al.
Publicado: (2022)

Uncovering the universality of self-replication in protein aggregation and its link to disease
por: Meisl, Georg, et al.
Publicado: (2022)

The telomerase reverse transcriptase elongates reversed replication forks at telomeric repeats
por: Huda, Armela, et al.
Publicado: (2023)

Spatial resolution of an integrated C(4)+CAM photosynthetic metabolism
por: Moreno-Villena, Jose J., et al.
Publicado: (2022)

Cohesin-dependent chromosome loop extrusion is limited by transcription and stalled replication forks
por: Jeppsson, Kristian, et al.
Publicado: (2022)

An RNA-based system to study hepatitis B virus replication and evaluate antivirals
por: Yu, Yingpu, et al.
Publicado: (2023)

Data for all: Tactile graphics that light up with picture-perfect resolution
por: Koone, Jordan C., et al.
Publicado: (2022)

Dynamics and regulation of mitotic chromatin accessibility bookmarking at single-cell resolution
por: Yu, Qiaoni, et al.
Publicado: (2023)

Deciphering sources of PET signals in the tumor microenvironment of glioblastoma at cellular resolution
por: Bartos, Laura M., et al.
Publicado: (2023)

Amilorides inhibit SARS-CoV-2 replication in vitro by targeting RNA structures
por: Zafferani, Martina, et al.
Publicado: (2021)

Transient RNA structures cause aberrant influenza virus replication and innate immune activation
por: French, Hollie, et al.
Publicado: (2022)

More than bad luck: Cancer and aging are linked to replication-driven changes to the epigenome
por: Minteer, Christopher J., et al.
Publicado: (2023)

Molecular organization and mechanics of single vimentin filaments revealed by super-resolution imaging
por: Nunes Vicente, Filipe, et al.
Publicado: (2022)

High-resolution structure and dynamics of mitochondrial complex I—Insights into the proton pumping mechanism
por: Parey, Kristian, et al.
Publicado: (2021)

High-resolution cryo-EM structures of plant cytochrome b(6)f at work
por: Sarewicz, Marcin, et al.
Publicado: (2023)

RNA structures and dynamics with Å resolution revealed by x-ray free-electron lasers
por: Zielinski, Kara A., et al.
Publicado: (2023)

Aspirin activates resolution pathways to reprogram T cell and macrophage responses in colitis-associated colorectal cancer
por: De Matteis, Roberta, et al.
Publicado: (2022)

Structures of neurokinin 1 receptor in complex with G(q) and G(s) proteins reveal substance P binding mode and unique activation features
por: Thom, Cristian, et al.
Publicado: (2021)

High-resolution cryo-EM structure of the Shigella virus Sf6 genome delivery tail machine
por: Li, Fenglin, et al.
Publicado: (2022)

6mA-Sniper: Quantifying 6mA sites in eukaryotes at single-nucleotide resolution
por: Zhang, Jie, et al.
Publicado: (2023)

Hepatoviruses promote very-long-chain fatty acid and sphingolipid synthesis for viral RNA replication and quasi-enveloped virus release
por: Shiota, Tomoyuki, et al.
Publicado: (2023)

Investigation of hydrated channels and proton pathways in a high-resolution cryo-EM structure of mammalian complex I
por: Grba, Daniel N., et al.
Publicado: (2023)

Charting a high-resolution roadmap for regeneration of pancreatic β cells by in vivo transdifferentiation from adult acinar cells
por: Liu, Gang, et al.
Publicado: (2023)

Plastic degradation by insect hexamerins: Near-atomic resolution structures of the polyethylene-degrading proteins from the wax worm saliva
por: Spínola-Amilibia, Mercedes, et al.
Publicado: (2023)

DDM1-mediated R-loop resolution and H2A.Z exclusion facilitates heterochromatin formation in Arabidopsis
por: Zhou, Jincong, et al.
Publicado: (2023)

Structure of S1PR2–heterotrimeric G(13) signaling complex
por: Chen, Hongwen, et al.
Publicado: (2022)

Structural insights into G protein activation by D1 dopamine receptor
por: Teng, Xiao, et al.
Publicado: (2022)

Ribosome changes reprogram translation for chemosurvival in G0 leukemic cells
por: Datta, Chandreyee, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_dmte10bnjcad9qflsu4hiahkee