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Multistep mechanism of G-quadruplex resolution during DNA replication

G-quadruplex (or G4) structures form in guanine-rich DNA sequences and threaten genome stability when not properly resolved. G4 unwinding occurs during S phase via an unknown mechanism. Using Xenopus egg extracts, we define a three-step G4 unwinding mechanism that acts during DNA replication. First,...

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Detalles Bibliográficos
Autores principales:	Sato, Koichi, Martin-Pintado, Nerea, Post, Harm, Altelaar, Maarten, Knipscheer, Puck
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2021
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8462899/ https://www.ncbi.nlm.nih.gov/pubmed/34559566 http://dx.doi.org/10.1126/sciadv.abf8653

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