Design and evaluation of glutathione responsive glycosylated camptothecin nanosupramolecular prodrug

A novel tumor-targeted glutathione responsive Glycosylated-Camptothecin nanosupramolecular prodrug (CPT-GL NSp) was designed and fabricated via a disulfide bond. The effects of glycoligand with different polarities on solubility, self-assembly, stability, cellular uptake, and glutathione responsive...

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Detalles Bibliográficos
Autores principales: Li, Wenhua, Chen, Zhong, Liu, Xiaoying, Lian, Mingming, Peng, Haisheng, Zhang, Changmei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8462909/
https://www.ncbi.nlm.nih.gov/pubmed/34519602
http://dx.doi.org/10.1080/10717544.2021.1977424
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author Li, Wenhua
Chen, Zhong
Liu, Xiaoying
Lian, Mingming
Peng, Haisheng
Zhang, Changmei
author_facet Li, Wenhua
Chen, Zhong
Liu, Xiaoying
Lian, Mingming
Peng, Haisheng
Zhang, Changmei
author_sort Li, Wenhua
collection PubMed
description A novel tumor-targeted glutathione responsive Glycosylated-Camptothecin nanosupramolecular prodrug (CPT-GL NSp) was designed and fabricated via a disulfide bond. The effects of glycoligand with different polarities on solubility, self-assembly, stability, cellular uptake, and glutathione responsive cleaving were explored, and an optimal glycosylated ligand was selected for nanosupramolecular prodrug. It has been found that CPT-GL NSp exhibited higher drug loading than traditional nanoparticles. Among of which maltose modified NSp had the strongest anti-tumor effects than that of glucose and maltotriose. CPT-SS-Maltose had a similar anti-tumor ability to Irinotecan (IR), but the superior performance in solubility, hemolysis, and uptake of HepG2 cells.
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spelling pubmed-84629092021-09-25 Design and evaluation of glutathione responsive glycosylated camptothecin nanosupramolecular prodrug Li, Wenhua Chen, Zhong Liu, Xiaoying Lian, Mingming Peng, Haisheng Zhang, Changmei Drug Deliv Research Article A novel tumor-targeted glutathione responsive Glycosylated-Camptothecin nanosupramolecular prodrug (CPT-GL NSp) was designed and fabricated via a disulfide bond. The effects of glycoligand with different polarities on solubility, self-assembly, stability, cellular uptake, and glutathione responsive cleaving were explored, and an optimal glycosylated ligand was selected for nanosupramolecular prodrug. It has been found that CPT-GL NSp exhibited higher drug loading than traditional nanoparticles. Among of which maltose modified NSp had the strongest anti-tumor effects than that of glucose and maltotriose. CPT-SS-Maltose had a similar anti-tumor ability to Irinotecan (IR), but the superior performance in solubility, hemolysis, and uptake of HepG2 cells. Taylor & Francis 2021-09-14 /pmc/articles/PMC8462909/ /pubmed/34519602 http://dx.doi.org/10.1080/10717544.2021.1977424 Text en © 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Li, Wenhua
Chen, Zhong
Liu, Xiaoying
Lian, Mingming
Peng, Haisheng
Zhang, Changmei
Design and evaluation of glutathione responsive glycosylated camptothecin nanosupramolecular prodrug
title Design and evaluation of glutathione responsive glycosylated camptothecin nanosupramolecular prodrug
title_full Design and evaluation of glutathione responsive glycosylated camptothecin nanosupramolecular prodrug
title_fullStr Design and evaluation of glutathione responsive glycosylated camptothecin nanosupramolecular prodrug
title_full_unstemmed Design and evaluation of glutathione responsive glycosylated camptothecin nanosupramolecular prodrug
title_short Design and evaluation of glutathione responsive glycosylated camptothecin nanosupramolecular prodrug
title_sort design and evaluation of glutathione responsive glycosylated camptothecin nanosupramolecular prodrug
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8462909/
https://www.ncbi.nlm.nih.gov/pubmed/34519602
http://dx.doi.org/10.1080/10717544.2021.1977424
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