Cargando…

Design and evaluation of glutathione responsive glycosylated camptothecin nanosupramolecular prodrug

A novel tumor-targeted glutathione responsive Glycosylated-Camptothecin nanosupramolecular prodrug (CPT-GL NSp) was designed and fabricated via a disulfide bond. The effects of glycoligand with different polarities on solubility, self-assembly, stability, cellular uptake, and glutathione responsive...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Wenhua, Chen, Zhong, Liu, Xiaoying, Lian, Mingming, Peng, Haisheng, Zhang, Changmei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8462909/ https://www.ncbi.nlm.nih.gov/pubmed/34519602 http://dx.doi.org/10.1080/10717544.2021.1977424

Ejemplares similares

Glutathione‐Responsive Nanoparticles of Camptothecin Prodrug for Cancer Therapy
por: Zhang, Lingpu, et al.
Publicado: (2022)

PSMA-Oriented Target Delivery of Novel Anticancer Prodrugs: Design, Synthesis, and Biological Evaluations of Oligopeptide-Camptothecin Conjugates
por: Xu, Bing, et al.
Publicado: (2018)

Development of a Prodrug of Camptothecin for Enhanced Treatment of Glioblastoma Multiforme
por: Checa-Chavarria, Elisa, et al.
Publicado: (2021)

Evaluation of Nitrobenzyl Derivatives of Camptothecin as Anti-Cancer Agents and Potential Hypoxia Targeting Prodrugs
por: Liang, Dinghua, et al.
Publicado: (2018)

Reactive oxygen species activated by mitochondria-specific camptothecin prodrug for enhanced chemotherapy
por: Guo, Zhaopei, et al.
Publicado: (2022)

Novel glycosyl prodrug of RXP03 as MMP-11 prodrug: design, synthesis and virtual screening
por: Abdou, Moaz M., et al.
Publicado: (2023)

Carrier-free nanoparticles of camptothecin prodrug for chemo-photothermal therapy: the making, in vitro and in vivo testing
por: Ao, Mingtao, et al.
Publicado: (2021)

Glutathione Transferase (GST)-Activated Prodrugs
por: Ruzza, Paolo, et al.
Publicado: (2013)

An Orally Bioavailable (Mice) Prodrug of Glutathione
por: Crankshaw, Daune L., et al.
Publicado: (2021)

Supramolecular Crafting of Self-Assembling Camptothecin Prodrugs with Enhanced Efficacy against Primary Cancer Cells
por: Su, Hao, et al.
Publicado: (2016)

Self-Assembled Disulfide Bond Bearing Paclitaxel—Camptothecin Prodrug Nanoparticle for Lung Cancer Therapy
por: Gao, Jingyan, et al.
Publicado: (2020)

Prodrug Approach for Increasing Cellular Glutathione Levels
por: Cacciatore, Ivana, et al.
Publicado: (2010)

Sustained delivery of a camptothecin prodrug – CZ48 by nanosuspensions with improved pharmacokinetics and enhanced anticancer activity
por: Dong, Dong, et al.
Publicado: (2019)

Glutathione S-conjugates as prodrugs to target drug-resistant tumors
por: Ramsay, Emma E., et al.
Publicado: (2014)

Synthesis, Biological Evaluation and Low-Toxic Formulation Development of Glycosylated Paclitaxel Prodrugs
por: Mao, Yukang, et al.
Publicado: (2018)

Characterization of DNA Topoisomerase-1 in Spodoptera exigua for Toxicity Evaluation of Camptothecin and Hydoxy-Camptothecin
por: Zhang, Lan, et al.
Publicado: (2013)

Structurally defined tandem-responsive nanoassemblies composed of dipeptide-based photosensitive derivatives and hypoxia-activated camptothecin prodrugs against primary and metastatic breast tumors
por: Sun, Mengchi, et al.
Publicado: (2022)

Synthesis and Evaluation of Camptothecin Antibody–Drug Conjugates
por: Li, Wei, et al.
Publicado: (2019)

Maleimidation of dextran and the application in designing a dextran–camptothecin conjugate
por: Zhu, Qiwen, et al.
Publicado: (2018)

Role of human glutathione transferases in biotransformation of the nitric oxide prodrug JS-K
por: Sjödin, Birgitta, et al.
Publicado: (2021)

A novel glutathione-triggered theranostic prodrug for anticancer and imaging in living cells
por: Zhang, Hengrui, et al.
Publicado: (2018)

A platinum(IV) prodrug strategy to overcome glutathione-based oxaliplatin resistance
por: Fronik, Philipp, et al.
Publicado: (2022)

Effects of the combination of camptothecin and doxorubicin or etoposide on rat glioma cells and camptothecin-resistant variants
por: Pavillard, V, et al.
Publicado: (2001)

Nano-Drug Design Based on the Physiological Properties of Glutathione
por: Li, Wenhua, et al.
Publicado: (2021)

Role of synergy and immunostimulation in design of chemotherapy combinations: An analysis of doxorubicin and camptothecin
por: Pusuluri, Anusha, et al.
Publicado: (2019)

Glutathione boosting the cytotoxicity of a magnetic platinum(iv) nano-prodrug in tumor cells
por: Zhu, Zhenzhu, et al.
Publicado: (2016)

Lysine-mediated hydroxyethyl starch-10-hydroxy camptothecin micelles for the treatment of liver cancer
por: Li, Guofei, et al.
Publicado: (2020)

Camptothecin-based nanodrug delivery systems
por: Wen, Yan, et al.
Publicado: (2017)

Glutathione-Responsive Selenosulfide Prodrugs as a Platform Strategy for Potent and Selective Mechanism-Based Inhibition of Protein Tyrosine Phosphatases
por: Tjin, Caroline Chandra, et al.
Publicado: (2017)

Design, Synthesis, and In Vitro Evaluation of the Photoactivatable Prodrug of the PARP Inhibitor Talazoparib
por: Li, Jiaguo, et al.
Publicado: (2020)

Design, Synthesis, and Biological Evaluations of Tumor-Targeting Dual-Warhead Conjugates for a Taxoid–Camptothecin Combination Chemotherapy
por: Vineberg, Jacob G., et al.
Publicado: (2014)

Mitochondria-Targeted Delivery of Camptothecin Based on HPMA Copolymer for Metastasis Suppression
por: Yi, Xiaoli, et al.
Publicado: (2022)

Current perspectives on camptothecins in cancer treatment.
por: Dancey, J., et al.
Publicado: (1996)

Production of camptothecin in cultures of Chonemorpha grandiflora
por: Kulkarni, A. V., et al.
Publicado: (2010)

The combination of olaparib and camptothecin for effective radiosensitization
por: Miura, Katsutoshi, et al.
Publicado: (2012)

Chromatin determinants impart camptothecin sensitivity
por: Puddu, Fabio, et al.
Publicado: (2017)

H(2)O(2)-responsive polymer prodrug nanoparticles with glutathione scavenger for enhanced chemo-photodynamic synergistic cancer therapy
por: Wang, Guanchun, et al.
Publicado: (2023)

Development of an enzyme-linked immunosorbent assay for camptothecin
por: Yan, Liting, et al.
Publicado: (2019)

Editorial: Prodrug design and therapeutic applications
por: Xiao, Qicai, et al.
Publicado: (2023)

Divergent camptothecin biosynthetic pathway in Ophiorrhiza pumila
por: Yang, Mengquan, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_2nt90re8safeabe9mb9g8rtfqc