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Bright line or lottery? On significance and value in medical decision making
It is widely acknowledged that using p-value thresholds as the basis for making decision on health care spending is not appropriate. In the context of medical decision making, we argue that patient preferences need to be a stronger factor. Depending on attitudes to risk, patients might prefer a medi...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Routledge
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8462922/ https://www.ncbi.nlm.nih.gov/pubmed/34567476 http://dx.doi.org/10.1080/20016689.2021.1981574 |
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author | Mahlich, Jörg Dheban, Srirangan |
author_facet | Mahlich, Jörg Dheban, Srirangan |
author_sort | Mahlich, Jörg |
collection | PubMed |
description | It is widely acknowledged that using p-value thresholds as the basis for making decision on health care spending is not appropriate. In the context of medical decision making, we argue that patient preferences need to be a stronger factor. Depending on attitudes to risk, patients might prefer a medical treatment that performs on average worse than a comparator but offers a small probability of a large gain such as a cure. However, what has been labeled ‘value of hope’ is not yet fully reflected in the decision-making process of drug approval and health technology assessment (HTA). Therefore, patient risk preferences should be formally incorporated within the decision-making framework for regulatory and reimbursement decisions. |
format | Online Article Text |
id | pubmed-8462922 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Routledge |
record_format | MEDLINE/PubMed |
spelling | pubmed-84629222021-09-25 Bright line or lottery? On significance and value in medical decision making Mahlich, Jörg Dheban, Srirangan J Mark Access Health Policy Short Communication It is widely acknowledged that using p-value thresholds as the basis for making decision on health care spending is not appropriate. In the context of medical decision making, we argue that patient preferences need to be a stronger factor. Depending on attitudes to risk, patients might prefer a medical treatment that performs on average worse than a comparator but offers a small probability of a large gain such as a cure. However, what has been labeled ‘value of hope’ is not yet fully reflected in the decision-making process of drug approval and health technology assessment (HTA). Therefore, patient risk preferences should be formally incorporated within the decision-making framework for regulatory and reimbursement decisions. Routledge 2021-09-20 /pmc/articles/PMC8462922/ /pubmed/34567476 http://dx.doi.org/10.1080/20016689.2021.1981574 Text en © 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Short Communication Mahlich, Jörg Dheban, Srirangan Bright line or lottery? On significance and value in medical decision making |
title | Bright line or lottery? On significance and value in medical decision making |
title_full | Bright line or lottery? On significance and value in medical decision making |
title_fullStr | Bright line or lottery? On significance and value in medical decision making |
title_full_unstemmed | Bright line or lottery? On significance and value in medical decision making |
title_short | Bright line or lottery? On significance and value in medical decision making |
title_sort | bright line or lottery? on significance and value in medical decision making |
topic | Short Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8462922/ https://www.ncbi.nlm.nih.gov/pubmed/34567476 http://dx.doi.org/10.1080/20016689.2021.1981574 |
work_keys_str_mv | AT mahlichjorg brightlineorlotteryonsignificanceandvalueinmedicaldecisionmaking AT dhebansrirangan brightlineorlotteryonsignificanceandvalueinmedicaldecisionmaking |