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Bright line or lottery? On significance and value in medical decision making

It is widely acknowledged that using p-value thresholds as the basis for making decision on health care spending is not appropriate. In the context of medical decision making, we argue that patient preferences need to be a stronger factor. Depending on attitudes to risk, patients might prefer a medi...

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Detalles Bibliográficos
Autores principales: Mahlich, Jörg, Dheban, Srirangan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Routledge 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8462922/
https://www.ncbi.nlm.nih.gov/pubmed/34567476
http://dx.doi.org/10.1080/20016689.2021.1981574
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author Mahlich, Jörg
Dheban, Srirangan
author_facet Mahlich, Jörg
Dheban, Srirangan
author_sort Mahlich, Jörg
collection PubMed
description It is widely acknowledged that using p-value thresholds as the basis for making decision on health care spending is not appropriate. In the context of medical decision making, we argue that patient preferences need to be a stronger factor. Depending on attitudes to risk, patients might prefer a medical treatment that performs on average worse than a comparator but offers a small probability of a large gain such as a cure. However, what has been labeled ‘value of hope’ is not yet fully reflected in the decision-making process of drug approval and health technology assessment (HTA). Therefore, patient risk preferences should be formally incorporated within the decision-making framework for regulatory and reimbursement decisions.
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spelling pubmed-84629222021-09-25 Bright line or lottery? On significance and value in medical decision making Mahlich, Jörg Dheban, Srirangan J Mark Access Health Policy Short Communication It is widely acknowledged that using p-value thresholds as the basis for making decision on health care spending is not appropriate. In the context of medical decision making, we argue that patient preferences need to be a stronger factor. Depending on attitudes to risk, patients might prefer a medical treatment that performs on average worse than a comparator but offers a small probability of a large gain such as a cure. However, what has been labeled ‘value of hope’ is not yet fully reflected in the decision-making process of drug approval and health technology assessment (HTA). Therefore, patient risk preferences should be formally incorporated within the decision-making framework for regulatory and reimbursement decisions. Routledge 2021-09-20 /pmc/articles/PMC8462922/ /pubmed/34567476 http://dx.doi.org/10.1080/20016689.2021.1981574 Text en © 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communication
Mahlich, Jörg
Dheban, Srirangan
Bright line or lottery? On significance and value in medical decision making
title Bright line or lottery? On significance and value in medical decision making
title_full Bright line or lottery? On significance and value in medical decision making
title_fullStr Bright line or lottery? On significance and value in medical decision making
title_full_unstemmed Bright line or lottery? On significance and value in medical decision making
title_short Bright line or lottery? On significance and value in medical decision making
title_sort bright line or lottery? on significance and value in medical decision making
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8462922/
https://www.ncbi.nlm.nih.gov/pubmed/34567476
http://dx.doi.org/10.1080/20016689.2021.1981574
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