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HIV Broadly Neutralizing Antibodies Expressed as IgG3 Preserve Neutralization Potency and Show Improved Fc Effector Function

The ability of several broadly neutralizing antibodies (bNAbs) to protect against HIV infection is enhanced through Fc receptor binding. Antibody isotype modulates this effect, with IgG3 associated with improved HIV control and vaccine efficacy. We recently showed that an IgG3 variant of bNAb CAP256...

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Detalles Bibliográficos
Autores principales:	Richardson, Simone I., Ayres, Frances, Manamela, Nelia P., Oosthuysen, Brent, Makhado, Zanele, Lambson, Bronwen E., Morris, Lynn, Moore, Penny L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8462932/ https://www.ncbi.nlm.nih.gov/pubmed/34566999 http://dx.doi.org/10.3389/fimmu.2021.733958

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