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The roles of T cells in obese adipose tissue inflammation

Adipose tissue inflammation in obese patients can cause a series of metabolic diseases. There are a variety of immune cells in adipose tissue, and studies have shown that T cells are associated with adipose tissue inflammation. This review aims to describe the current understanding of the relationsh...

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Detalles Bibliográficos
Autores principales: Wang, Qiong, Wang, Yurong, Xu, Danyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8463033/
https://www.ncbi.nlm.nih.gov/pubmed/34515616
http://dx.doi.org/10.1080/21623945.2021.1965314
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author Wang, Qiong
Wang, Yurong
Xu, Danyan
author_facet Wang, Qiong
Wang, Yurong
Xu, Danyan
author_sort Wang, Qiong
collection PubMed
description Adipose tissue inflammation in obese patients can cause a series of metabolic diseases. There are a variety of immune cells in adipose tissue, and studies have shown that T cells are associated with adipose tissue inflammation. This review aims to describe the current understanding of the relationship between T cells and adipose tissue inflammation, with a focus on regulation by T cell subtypes. Studies have shown that Th1, Th17 and CD8(+) T cells, which are important T cell subsets, can promote the development of adipose tissue inflammation, whereas Treg cells protect against inflammation, suggesting that targeting the mechanism by which T cell subtypes regulate adipose tissue inflammation is a potential therapeutic strategy for treating obesity. T cells play important roles in regulating obesity-associated adipose tissue inflammation, thus providing new research directions for the treatment of obesity. More studies are needed to clarify how T cell subtypes regulate adipose tissue inflammation to identify new treatments for obesity.
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spelling pubmed-84630332021-09-25 The roles of T cells in obese adipose tissue inflammation Wang, Qiong Wang, Yurong Xu, Danyan Adipocyte Review Adipose tissue inflammation in obese patients can cause a series of metabolic diseases. There are a variety of immune cells in adipose tissue, and studies have shown that T cells are associated with adipose tissue inflammation. This review aims to describe the current understanding of the relationship between T cells and adipose tissue inflammation, with a focus on regulation by T cell subtypes. Studies have shown that Th1, Th17 and CD8(+) T cells, which are important T cell subsets, can promote the development of adipose tissue inflammation, whereas Treg cells protect against inflammation, suggesting that targeting the mechanism by which T cell subtypes regulate adipose tissue inflammation is a potential therapeutic strategy for treating obesity. T cells play important roles in regulating obesity-associated adipose tissue inflammation, thus providing new research directions for the treatment of obesity. More studies are needed to clarify how T cell subtypes regulate adipose tissue inflammation to identify new treatments for obesity. Taylor & Francis 2021-09-13 /pmc/articles/PMC8463033/ /pubmed/34515616 http://dx.doi.org/10.1080/21623945.2021.1965314 Text en © 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Wang, Qiong
Wang, Yurong
Xu, Danyan
The roles of T cells in obese adipose tissue inflammation
title The roles of T cells in obese adipose tissue inflammation
title_full The roles of T cells in obese adipose tissue inflammation
title_fullStr The roles of T cells in obese adipose tissue inflammation
title_full_unstemmed The roles of T cells in obese adipose tissue inflammation
title_short The roles of T cells in obese adipose tissue inflammation
title_sort roles of t cells in obese adipose tissue inflammation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8463033/
https://www.ncbi.nlm.nih.gov/pubmed/34515616
http://dx.doi.org/10.1080/21623945.2021.1965314
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