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The roles of T cells in obese adipose tissue inflammation
Adipose tissue inflammation in obese patients can cause a series of metabolic diseases. There are a variety of immune cells in adipose tissue, and studies have shown that T cells are associated with adipose tissue inflammation. This review aims to describe the current understanding of the relationsh...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8463033/ https://www.ncbi.nlm.nih.gov/pubmed/34515616 http://dx.doi.org/10.1080/21623945.2021.1965314 |
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author | Wang, Qiong Wang, Yurong Xu, Danyan |
author_facet | Wang, Qiong Wang, Yurong Xu, Danyan |
author_sort | Wang, Qiong |
collection | PubMed |
description | Adipose tissue inflammation in obese patients can cause a series of metabolic diseases. There are a variety of immune cells in adipose tissue, and studies have shown that T cells are associated with adipose tissue inflammation. This review aims to describe the current understanding of the relationship between T cells and adipose tissue inflammation, with a focus on regulation by T cell subtypes. Studies have shown that Th1, Th17 and CD8(+) T cells, which are important T cell subsets, can promote the development of adipose tissue inflammation, whereas Treg cells protect against inflammation, suggesting that targeting the mechanism by which T cell subtypes regulate adipose tissue inflammation is a potential therapeutic strategy for treating obesity. T cells play important roles in regulating obesity-associated adipose tissue inflammation, thus providing new research directions for the treatment of obesity. More studies are needed to clarify how T cell subtypes regulate adipose tissue inflammation to identify new treatments for obesity. |
format | Online Article Text |
id | pubmed-8463033 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-84630332021-09-25 The roles of T cells in obese adipose tissue inflammation Wang, Qiong Wang, Yurong Xu, Danyan Adipocyte Review Adipose tissue inflammation in obese patients can cause a series of metabolic diseases. There are a variety of immune cells in adipose tissue, and studies have shown that T cells are associated with adipose tissue inflammation. This review aims to describe the current understanding of the relationship between T cells and adipose tissue inflammation, with a focus on regulation by T cell subtypes. Studies have shown that Th1, Th17 and CD8(+) T cells, which are important T cell subsets, can promote the development of adipose tissue inflammation, whereas Treg cells protect against inflammation, suggesting that targeting the mechanism by which T cell subtypes regulate adipose tissue inflammation is a potential therapeutic strategy for treating obesity. T cells play important roles in regulating obesity-associated adipose tissue inflammation, thus providing new research directions for the treatment of obesity. More studies are needed to clarify how T cell subtypes regulate adipose tissue inflammation to identify new treatments for obesity. Taylor & Francis 2021-09-13 /pmc/articles/PMC8463033/ /pubmed/34515616 http://dx.doi.org/10.1080/21623945.2021.1965314 Text en © 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Wang, Qiong Wang, Yurong Xu, Danyan The roles of T cells in obese adipose tissue inflammation |
title | The roles of T cells in obese adipose tissue inflammation |
title_full | The roles of T cells in obese adipose tissue inflammation |
title_fullStr | The roles of T cells in obese adipose tissue inflammation |
title_full_unstemmed | The roles of T cells in obese adipose tissue inflammation |
title_short | The roles of T cells in obese adipose tissue inflammation |
title_sort | roles of t cells in obese adipose tissue inflammation |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8463033/ https://www.ncbi.nlm.nih.gov/pubmed/34515616 http://dx.doi.org/10.1080/21623945.2021.1965314 |
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