Structure and dynamics of the chromatin remodeler ALC1 bound to a PARylated nucleosome

The chromatin remodeler ALC1 is recruited to and activated by DNA damage-induced poly(ADP-ribose) (PAR) chains deposited by PARP1/PARP2/HPF1 upon detection of DNA lesions. ALC1 has emerged as a candidate drug target for cancer therapy as its loss confers synthetic lethality in homologous recombinati...

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Detalles Bibliográficos
Autores principales: Bacic, Luka, Gaullier, Guillaume, Sabantsev, Anton, Lehmann, Laura C, Brackmann, Klaus, Dimakou, Despoina, Halic, Mario, Hewitt, Graeme, Boulton, Simon J, Deindl, Sebastian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Chromosomes and Gene Expression
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8463071/
https://www.ncbi.nlm.nih.gov/pubmed/34486521
http://dx.doi.org/10.7554/eLife.71420

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