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Cyclin-dependent kinases-based synthetic lethality: Evidence, concept, and strategy
Synthetic lethality is a proven effective antitumor strategy that has attracted great attention. Large-scale screening has revealed many synthetic lethal genetic phenotypes, and relevant small-molecule drugs have also been implemented in clinical practice. Increasing evidence suggests that CDKs, con...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8463275/ https://www.ncbi.nlm.nih.gov/pubmed/34589394 http://dx.doi.org/10.1016/j.apsb.2021.01.002 |