Cargando…

Design, synthesis, and biological evaluation of multiple targeting antimalarials

Malaria still threatens global health seriously today. While the current discoveries of antimalarials are almost totally focused on single mode-of-action inhibitors, multi-targeting inhibitors are highly desired to overcome the increasingly serious drug resistance. Here, we performed a structure-bas...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yang, Yiqing, Tang, Tongke, Li, Xiaolu, Michel, Thomas, Ling, Liqin, Huang, Zhenghui, Mulaka, Maruthi, Wu, Yue, Gao, Hongying, Wang, Liguo, Zhou, Jing, Meunier, Brigitte, Ke, Hangjun, Jiang, Lubin, Rao, Yu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8463279/ https://www.ncbi.nlm.nih.gov/pubmed/34589403 http://dx.doi.org/10.1016/j.apsb.2021.05.008

Ejemplares similares

Dispensable Role of Mitochondrial Fission Protein 1 (Fis1) in the Erythrocytic Development of Plasmodium falciparum
por: Maruthi, Mulaka, et al.
Publicado: (2020)

Cdk7 mediates RPB1-driven mRNA synthesis in Toxoplasma gondii
por: Deshmukh, Abhijit S., et al.
Publicado: (2016)

Advances in aggregation induced emission (AIE) materials in biosensing and imaging of bacteria
por: Maruthi, Mulaka, et al.
Publicado: (2021)

Synthesis and Antimalarial Activities of New Hybrid Atokel Molecules
por: Li, Youzhi, et al.
Publicado: (2022)

New Potential Antimalarial Agents: Design, Synthesis and Biological Evaluation of Some Novel Quinoline Derivatives as Antimalarial Agents
por: Radini, Ibrahim Ali M., et al.
Publicado: (2016)

Biocompatible Drug Delivery System Based on a MOF Platform for a Sustained and Controlled Release of the Poorly Soluble Drug Norfloxacin
por: Yadav, Preety, et al.
Publicado: (2023)

Design, synthesis and biological evaluation of antimalarial activity of new derivatives of 2,4,6-s-triazine
por: Pathak, Mallika, et al.
Publicado: (2017)

Synthesis of Benzocycloalkanone-Based Michael Acceptors and Biological Activities as Antimalarial and Antitrypanosomal Agents
por: Mijoba, Ali, et al.
Publicado: (2023)

Synthesis of New β-Lactams Bearing the Biologically Important Morpholine Ring and POM Analyses of Their Antimicrobial and Antimalarial Activities
por: Jarrahpour, Aliasghar, et al.
Publicado: (2019)

Synthesis of New Triazolopyrazine Antimalarial Compounds
por: Johnson, Daniel J. G., et al.
Publicado: (2021)

Lerisetron Analogues with Antimalarial Properties: Synthesis, Structure–Activity Relationship Studies, and Biological Assessment
por: Mueller, Rudolf, et al.
Publicado: (2020)

Diastereoselective Synthesis of Potent Antimalarial Cis-β-lactam Agents
por: Jarrahpour, Aliasghar, et al.
Publicado: (2019)

Pharmacomodulation of the Antimalarial Plasmodione: Synthesis of Biaryl- and N-Arylalkylamine Analogues, Antimalarial Activities and Physicochemical Properties
por: Urgin, Karène, et al.
Publicado: (2017)

Synthesis and Potent Antimalarial Activity of Kalihinol B
por: Daub, Mary Elisabeth, et al.
Publicado: (2015)

An Efficient and Sustainable Synthesis of the Antimalarial Drug Tafenoquine
por: Kavthe, Rahul D., et al.
Publicado: (2022)

The antimalarial drug primaquine targets Fe–S cluster proteins and yeast respiratory growth
por: Lalève, Anaïs, et al.
Publicado: (2015)

Antimalarial Inhibitors Targeting Epigenetics or Mitochondria in Plasmodium falciparum: Recent Survey upon Synthesis and Biological Evaluation of Potential Drugs against Malaria
por: Koumpoura, Christina L., et al.
Publicado: (2021)

Design, Synthesis and Evaluation of Bifunctional Acridinine−Naphthalenediimide Redox-Active Conjugates as Antimalarials
por: Dana, Srikanta, et al.
Publicado: (2016)

Synthesis and Evaluation of α-Thymidine Analogues as Novel Antimalarials
por: Cui, Huaqing, et al.
Publicado: (2012)

Synthesis and Antimalarial Activity of Mallatojaponin C and Related Compounds
por: Eaton, Alexander L., et al.
Publicado: (2016)

Synthesis and Antimalarial Activity of Novel Dihydro-Artemisinin Derivatives
por: Liu, Yang, et al.
Publicado: (2011)

Synthesis of Plasmepsin II Inhibitors – Potential Antimalarial Agents
por: Mueller, Reto, et al.
Publicado: (2003)

Synthesis and characterisation of new antimalarial fluorinated triazolopyrazine compounds
por: Lum, Kah Yean, et al.
Publicado: (2023)

Synthesis and Antimalarial Evaluation of Halogenated Analogues of Thiaplakortone A
por: Egbewande, Folake A., et al.
Publicado: (2023)

Transcriptional changes in Plasmodium falciparum upon conditional knock down of mitochondrial ribosomal proteins RSM22 and L23
por: Dass, Swati, et al.
Publicado: (2022)

Biological synthesis of silver nanoparticles from Adansonia digitata L. fruit pulp extract, characterization, and its antimicrobial properties
por: Kumar, Chennareddy Maruthi Kesava, et al.
Publicado: (2016)

New pyrazolylpyrazoline derivatives as dual acting antimalarial-antileishamanial agents: synthesis, biological evaluation and molecular modelling simulations
por: Bekhit, Adnan A., et al.
Publicado: (2022)

Hydroxyethylamine Based Phthalimides as New Class of Plasmepsin Hits: Design, Synthesis and Antimalarial Evaluation
por: Singh, Anil K., et al.
Publicado: (2015)

High-yielding continuous-flow synthesis of antimalarial drug hydroxychloroquine
por: Yu, Eric, et al.
Publicado: (2018)

Synthesis and antimalarial potential of some novel quinoline-pyrazolopyridine derivatives
por: Saini, Deepika, et al.
Publicado: (2016)

Enantioselective Synthesis and in Vivo Evaluation of Regioisomeric Analogues of the Antimalarial Arterolane
por: Blank, Brian R., et al.
Publicado: (2017)

Synthesis and Antimalarial Activity of 1,4-Disubstituted Piperidine Derivatives
por: Seck, Rokhyatou, et al.
Publicado: (2020)

Synthesis and antiplasmodial assessment of nitazoxanide and analogs as new antimalarial candidates
por: Irabuena, Camila, et al.
Publicado: (2022)

Environmentally Responsible and Cost-Effective Synthesis of the Antimalarial Drug Pyronaridine
por: Kincaid, Joseph R. A., et al.
Publicado: (2022)

Design and Synthesis of C-1 Methoxycarbonyl Derivative of Narciclasine and Its Biological Activity
por: Habaz, Lihi, et al.
Publicado: (2022)

An affordable antimalarial.
por: Tenenbaum, David J
Publicado: (2004)

Marine Antimalarials
por: Fattorusso, Ernesto, et al.
Publicado: (2009)

Synthetic Antimalarials
Publicado: (1955)

Antimalarial Drug Resistance and Novel Targets for Antimalarial Drug Discovery
por: Shibeshi, Melkamu Adigo, et al.
Publicado: (2020)

Synthesis and antimalarial evaluation of some 4-quinazolinone derivatives based on febrifugine
por: Sen, Debanjan, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_ls0711tmh3k9rcpng6dntfqlvv