Modeling a cataract disorder in mice with prime editing

Prime editing enables efficient introduction of targeted transversions, insertions, and deletions in mammalian cells and several organisms. However, genetic disease models with base deletions by prime editing have not yet been reported in mice. Here, we successfully generate a mouse model with a cat...

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Detalles Bibliográficos
Autores principales: Lin, Jianxiang, Liu, Xingchen, Lu, Zongyang, Huang, Shisheng, Wu, Susu, Yu, Wenxia, Liu, Yao, Zheng, Xiaoguo, Huang, Xingxu, Sun, Qiang, Qiao, Yunbo, Liu, Zhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8463286/
https://www.ncbi.nlm.nih.gov/pubmed/34589272
http://dx.doi.org/10.1016/j.omtn.2021.06.020

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8463286/
https://www.ncbi.nlm.nih.gov/pubmed/34589272
http://dx.doi.org/10.1016/j.omtn.2021.06.020

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