Cargando…
Modeling a cataract disorder in mice with prime editing
Prime editing enables efficient introduction of targeted transversions, insertions, and deletions in mammalian cells and several organisms. However, genetic disease models with base deletions by prime editing have not yet been reported in mice. Here, we successfully generate a mouse model with a cat...
Autores principales: | Lin, Jianxiang, Liu, Xingchen, Lu, Zongyang, Huang, Shisheng, Wu, Susu, Yu, Wenxia, Liu, Yao, Zheng, Xiaoguo, Huang, Xingxu, Sun, Qiang, Qiao, Yunbo, Liu, Zhen |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society of Gene & Cell Therapy
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8463286/ https://www.ncbi.nlm.nih.gov/pubmed/34589272 http://dx.doi.org/10.1016/j.omtn.2021.06.020 |
Ejemplares similares
-
Base editing‐mediated perturbation of endogenous PKM1/2 splicing facilitates isoform‐specific functional analysis in vitro and in vivo
por: Lin, Jianxiang, et al.
Publicado: (2021) -
High-resolution annotation of the mouse preimplantation embryo transcriptome using long-read sequencing
por: Qiao, Yunbo, et al.
Publicado: (2020) -
Author Correction: High-resolution annotation of the mouse preimplantation embryo transcriptome using long-read sequencing
por: Qiao, Yunbo, et al.
Publicado: (2021) -
Efficient generation of mouse models of human diseases via ABE- and BE-mediated base editing
por: Liu, Zhen, et al.
Publicado: (2018) -
Enhancement of prime editing via xrRNA motif-joined pegRNA
por: Zhang, Guiquan, et al.
Publicado: (2022)