Feasibility of cRGD conjugation at 5′-antisense strand of siRNA by phosphodiester linkage extension

Small interfering RNAs (siRNAs) are widely studied for their highly specific gene silencing activity. However, obstacles remain to the clinical application of siRNAs. Attaching conjugates to siRNAs can improve their stability and broaden their application, and most functional conjugates of siRNAs lo...

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Detalles Bibliográficos
Autores principales: Zhou, Xinyang, Pan, Yufei, Yu, Lijia, Wu, Jing, Li, Zheng, Li, Huantong, Guan, Zhu, Tang, Xinjing, Yang, Zhenjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8463321/
https://www.ncbi.nlm.nih.gov/pubmed/34589281
http://dx.doi.org/10.1016/j.omtn.2021.08.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8463321/
https://www.ncbi.nlm.nih.gov/pubmed/34589281
http://dx.doi.org/10.1016/j.omtn.2021.08.004

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