ERα determines the chemo-resistant function of mutant p53 involving the switch between lincRNA-p21 and DDB2 expressions

Mutant p53 (mutp53) commonly loses its DNA binding affinity to p53 response elements (p53REs) and fails to induce apoptosis fully. However, the p53 mutation does not predict chemoresistance in all subtypes of breast cancers, and the critical determinants remain to be identified. In this study, mutp5...

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Detalles Bibliográficos
Autores principales: He, Yu-Hao, Yeh, Ming-Hsin, Chen, Hsiao-Fan, Wang, Tsu-Shing, Wong, Ruey-Hong, Wei, Ya-Ling, Huynh, Thanh Kieu, Hu, Dai-Wei, Cheng, Fang-Ju, Chen, Jhen-Yu, Hu, Shu-Wei, Huang, Chia-Chen, Chen, Yeh, Yu, Jiaxin, Cheng, Wei-Chung, Shen, Pei-Chun, Liu, Liang-Chih, Huang, Chih-Hao, Chang, Ya-Jen, Huang, Wei-Chien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8463322/
https://www.ncbi.nlm.nih.gov/pubmed/34589276
http://dx.doi.org/10.1016/j.omtn.2021.07.022

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