Transfer of SCN1A to the brain of adolescent mouse model of Dravet syndrome improves epileptic, motor, and behavioral manifestations

Dravet syndrome is a genetic encephalopathy characterized by severe epilepsy combined with motor, cognitive, and behavioral abnormalities. Current antiepileptic drugs achieve only partial control of seizures and provide little benefit on the patient’s neurological development. In >80% of cases, t...

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Detalles Bibliográficos
Autores principales: Mora-Jimenez, Lucia, Valencia, Miguel, Sanchez-Carpintero, Rocio, Tønnesen, Jan, Fadila, Saja, Rubinstein, Moran, Gonzalez-Aparicio, Manuela, Bunuales, Maria, Fernandez-Pierola, Eva, Nicolas, Maria Jesus, Puerta, Elena, Miguelez, Cristina, Minguez, Paula Gimenez, Lumbreras, Sara, Gonzalez-Aseguinolaza, Gloria, Ricobaraza, Ana, Hernandez-Alcoceba, Ruben
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8463324/
https://www.ncbi.nlm.nih.gov/pubmed/34589280
http://dx.doi.org/10.1016/j.omtn.2021.08.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8463324/
https://www.ncbi.nlm.nih.gov/pubmed/34589280
http://dx.doi.org/10.1016/j.omtn.2021.08.003

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