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Simultaneous improvement to solubility and bioavailability of active natural compound isosteviol using cyclodextrin metal-organic frameworks

Cyclodextrin metal-organic framework (CD-MOF) as a highly porous supramolecular carrier could be one of the solutions to the insolubility of isosteviol (STV). The solubility of STV was lower than 20.00 ng/mL at pH 1.0 and pH 4.5, whilst its solubility increased to 20,074.30 ng/mL at pH 6.8 and 129.5...

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Detalles Bibliográficos
Autores principales:	Chen, Xiaojin, Guo, Tao, Zhang, Kaikai, Chen, Jiacai, Wang, Caifen, Ren, Xiaohong, Wang, Qin, Yang, Yingchao, Liu, Chongjing, Tan, Wen, Gui, Shuangying, Wu, Li, Zhang, Jiwen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8463510/ https://www.ncbi.nlm.nih.gov/pubmed/34589404 http://dx.doi.org/10.1016/j.apsb.2021.04.018

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