Cargando…

Profiling extra cellular matrix associated proteome of human fetal nucleus pulposus in search for regenerative targets

Degeneration of the intervertebral disc is associated with a decrease in extra-cellular matrix (ECM) content due to an imbalance in anabolic and catabolic signaling. Our previous study profiled the core matrisome of fetal NP’s and identified various proteins with anabolic potential for regenerative...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rajasekaran, Shanmuganathan, Thangavel, Chitra, Djuric, Niek, Raveendran, Muthurajan, Soundararajan, Dilip Chand Raja, Nayagam, Sharon Miracle, Matchado, Monica Steffi, Sri Vijay Anand, K. S., Venkateshwaran, Krishna
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8463528/ https://www.ncbi.nlm.nih.gov/pubmed/34561485 http://dx.doi.org/10.1038/s41598-021-97620-w

Ejemplares similares

Part 1: profiling extra cellular matrix core proteome of human fetal nucleus pulposus in search for regenerative targets
por: Rajasekaran, Shanmuganathan, et al.
Publicado: (2020)

Proteomic Signature of Nucleus Pulposus in Fetal Intervertebral Disc
por: Rajasekaran, Shanmuganathan, et al.
Publicado: (2020)

Comparative metagenomic analysis of human intervertebral disc nucleus pulposus and cartilaginous end plates
por: Shanmuganathan, Rajasekaran, et al.
Publicado: (2022)

Proteomic Signatures of Healthy Intervertebral Discs From Organ Donors: A Comparison With Previous Studies on Discs From Scoliosis, Animals, and Trauma
por: Rajasekaran, Shanmuganathan, et al.
Publicado: (2020)

Novel Biomarkers of Health and Degeneration in Human Intervertebral Discs: In-depth Proteomic Analysis of Collagen Framework of Fetal, Healthy, Scoliotic, Degenerate, and Herniated Discs
por: Rajasekaran, Shanmuganathan, et al.
Publicado: (2023)

Can Scoliotic Discs Be Controls for Molecular Studies in Intervertebral Disc Research? Insights From Proteomics
por: Rajasekaran, S., et al.
Publicado: (2020)

Motion-Preserving Navigated Primary Internal Fixation of Unstable C1 Fractures
por: Rajasekaran, Shanmuganathan, et al.
Publicado: (2020)

A Validated Score for Evaluating Spinal Instability to Assess Surgical Candidacy in Active Spinal Tuberculosis—An Evidence Based Approach and Multinational Expert Consensus Study
por: Rajasekaran, Shanmuganathan, et al.
Publicado: (2022)

Lumbar Disc Herniation and Preoperative Modic Changes: A Prospective Analysis of the Clinical Outcomes After Microdiscectomy
por: Kumarasamy, Dinesh, et al.
Publicado: (2021)

The Regenerative Potential of Notochordal Cells in a Nucleus Pulposus Explant
por: Arkesteijn, Irene T. M., et al.
Publicado: (2017)

Thoracolumbar Fracture Dislocations Without Spinal Cord Injury: Classification and Principles of Management
por: Kanna, Rishi Mugesh, et al.
Publicado: (2019)

The Effectiveness of Noninvasive Positive Pressure Ventilation in Subarachnoid Pleural Fistula: A Case Report and Literature Review
por: Soundararajan, Dilip Chand Raja, et al.
Publicado: (2018)

Spinal Tuberculosis: Current Concepts
por: Rajasekaran, S., et al.
Publicado: (2018)

Regenerative Response of Degenerate Human Nucleus Pulposus Cells to GDF6 Stimulation
por: Hodgkinson, Tom, et al.
Publicado: (2020)

Regenerative and Immunogenic Characteristics of Cultured Nucleus Pulposus Cells from Human Cervical Intervertebral Discs
por: Stich, Stefan, et al.
Publicado: (2015)

Sporadic Intradural Extramedullary Hemangioblastoma of Cauda Equina with Large Peritumoral Cyst—A Rare Presentation
por: Thippeswamy, Pushpa B., et al.
Publicado: (2022)

Surgical excision of heterotopic ossification of hip in a rare case of Moyamoya disease with extra articular ankylosis
por: Palanisami, Dhanasekararaja, et al.
Publicado: (2012)

A Well-Controlled Nucleus Pulposus Tissue Culture System with Injection Port for Evaluating Regenerative Therapies
por: Arkesteijn, Irene T. M., et al.
Publicado: (2015)

Notochordal-cell derived extracellular vesicles exert regenerative effects on canine and human nucleus pulposus cells
por: Bach, Frances, et al.
Publicado: (2017)

Schwannoma of the Posterior Tibial Nerve Presenting as Tarsal Tunnel Syndrome: A Case Report with Emphasis on the Role of Microscope during Surgery
por: Rajasekaran, Raja Bhaskara, et al.
Publicado: (2018)

An Inflammatory Nucleus Pulposus Tissue Culture Model to Test Molecular Regenerative Therapies: Validation with Epigallocatechin 3-Gallate
por: Krupkova, Olga, et al.
Publicado: (2016)

Plant Metabolomics: Current Initiatives and Future Prospects
por: Manickam, Sudha, et al.
Publicado: (2023)

Successful reconstruction of a post-traumatic defect of 16 cm of the distal femur by modified Capanna's technique (vascularised free fibula combined with allograft) – A case report and technical note
por: Rajasekaran, Raja Bhaskara, et al.
Publicado: (2018)

Modified Capanna’s Technique (Vascularized Free Fibula Combined with Allograft) as a Single-Stage Procedure in Post-traumatic Long-Segment Defects of the Lower End of the Femur: Outcome Analysis of a Series of 19 Patients with an Average Gap of 14 cm
por: Jayaramaraju, Dheenadhayalan, et al.
Publicado: (2019)

Shh Signaling from the Nucleus Pulposus Is Required for the Postnatal Growth and Differentiation of the Mouse Intervertebral Disc
por: Dahia, Chitra Lekha, et al.
Publicado: (2012)

Inducing Angiogenesis in the Nucleus Pulposus
por: Damle, Sheela R., et al.
Publicado: (2023)

Evaluation of Anti-inflammatory and Regenerative Efficiency of Naringin and Naringenin in Degenerated Human Nucleus Pulposus Cells: Biological and Molecular Modeling Studies
por: Devraj, Vijaya Madhuri, et al.
Publicado: (2019)

Spheroid Formation Enhances the Regenerative Capacity of Nucleus Pulposus Cells via Regulating N-CDH and ITGβ1 Interaction
por: Wang, Yiyang, et al.
Publicado: (2022)

Cauda equina syndrome in an obese pregnant patient secondary to double level lumbar disc herniation – A case report and review of literature
por: S, Dilip Chand Raja, et al.
Publicado: (2019)

Lumbar Intraspinal Osteolipoma Presenting as Cauda Equina Syndrome: A Case Report and Review of Literature
por: Dilip Chand Raja, S., et al.
Publicado: (2018)

Chondrocyte‐like nested cells in the aged intervertebral disc are late‐stage nucleus pulposus cells
por: Mohanty, Sarthak, et al.
Publicado: (2019)

Characterization of Krt19 (CreERT) allele for targeting the nucleus pulposus cells in the postnatal mouse intervertebral disc
por: Mohanty, Sarthak, et al.
Publicado: (2019)

Regenerative Capability of Human Nucleus Pulposus Cells in Degenerated Disc Under Hydrostatic Pressure Mimicking Physiologically Relevant Intradiscal Pressure In Vitro
por: Takeoka, Yoshiki, et al.
Publicado: (2023)

Collagen type II is downregulated in the degenerative nucleus pulposus and contributes to the degeneration and apoptosis of human nucleus pulposus cells
por: Lian, Chengjie, et al.
Publicado: (2017)

Ipsilateral Acetabular Fracture with Displaced Femoral Head and Femoral Shaft Fracture: A Complex Floating Hip Injury
por: Rajasekaran, Raja Bhaskara, et al.
Publicado: (2018)

Megaprosthesis in distal femur nonunions in elderly patients—experience from twenty four cases
por: Rajasekaran, Raja Bhaskara, et al.
Publicado: (2019)

Expansion of FGFR3-positive nucleus pulposus cells plays important roles in postnatal nucleus pulposus growth and regeneration
por: Xu, Meng, et al.
Publicado: (2022)

The enigma that is the nucleus pulposus cell: the search goes on
por: Erwin, W Mark
Publicado: (2010)

Bone Morphogenetic Proteins for Nucleus Pulposus Regeneration
por: Krouwels, Anita, et al.
Publicado: (2020)

Cell sources proposed for nucleus pulposus regeneration
por: Williams, Rebecca J., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_5d5si49buj5svtrlr89dgve6m9