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Persistence of functional microbiota composition across generations

Holobionts are defined as a host and its microbiota, however, only a fraction of the bacteria are inherited vertically and thus coevolve with the host. The “it’s the song, not the singer” theory proposes that functional traits, instead of taxonomical microbiota composition, could be preserved across...

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Detalles Bibliográficos
Autores principales: Ramos, Christian, Calus, Mario, Schokker, Dirkjan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8463531/
https://www.ncbi.nlm.nih.gov/pubmed/34561474
http://dx.doi.org/10.1038/s41598-021-98097-3
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author Ramos, Christian
Calus, Mario
Schokker, Dirkjan
author_facet Ramos, Christian
Calus, Mario
Schokker, Dirkjan
author_sort Ramos, Christian
collection PubMed
description Holobionts are defined as a host and its microbiota, however, only a fraction of the bacteria are inherited vertically and thus coevolve with the host. The “it’s the song, not the singer” theory proposes that functional traits, instead of taxonomical microbiota composition, could be preserved across generations if interspecies interaction patterns perpetuate themselves. We tested conservation of functional composition across generations using zooplankton, mosquito, and plant datasets. Then, we tested if there is a change of functional microbiota composition over time within a generation in human datasets. Finally, we simulated microbiota communities to investigate if (pairwise) interactions can lead to multiple stable community compositions. Our results suggest that the vertically transmitted microbiota starts a predictable change of functions performed by the microbiota over time, whose robustness depends on the arrival of diverse migrants. This succession culminates in a stable functional composition state. The results suggest that the host-microbiota interaction and higher order interactions in general have an important contribution to the robustness of the final community. If the proposed mechanism proves to be valid for a diverse array of host species, this would support the concept of holobionts being used as units of selection, including animal breeding, suggesting this has a wider applicability.
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spelling pubmed-84635312021-09-27 Persistence of functional microbiota composition across generations Ramos, Christian Calus, Mario Schokker, Dirkjan Sci Rep Article Holobionts are defined as a host and its microbiota, however, only a fraction of the bacteria are inherited vertically and thus coevolve with the host. The “it’s the song, not the singer” theory proposes that functional traits, instead of taxonomical microbiota composition, could be preserved across generations if interspecies interaction patterns perpetuate themselves. We tested conservation of functional composition across generations using zooplankton, mosquito, and plant datasets. Then, we tested if there is a change of functional microbiota composition over time within a generation in human datasets. Finally, we simulated microbiota communities to investigate if (pairwise) interactions can lead to multiple stable community compositions. Our results suggest that the vertically transmitted microbiota starts a predictable change of functions performed by the microbiota over time, whose robustness depends on the arrival of diverse migrants. This succession culminates in a stable functional composition state. The results suggest that the host-microbiota interaction and higher order interactions in general have an important contribution to the robustness of the final community. If the proposed mechanism proves to be valid for a diverse array of host species, this would support the concept of holobionts being used as units of selection, including animal breeding, suggesting this has a wider applicability. Nature Publishing Group UK 2021-09-24 /pmc/articles/PMC8463531/ /pubmed/34561474 http://dx.doi.org/10.1038/s41598-021-98097-3 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Ramos, Christian
Calus, Mario
Schokker, Dirkjan
Persistence of functional microbiota composition across generations
title Persistence of functional microbiota composition across generations
title_full Persistence of functional microbiota composition across generations
title_fullStr Persistence of functional microbiota composition across generations
title_full_unstemmed Persistence of functional microbiota composition across generations
title_short Persistence of functional microbiota composition across generations
title_sort persistence of functional microbiota composition across generations
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8463531/
https://www.ncbi.nlm.nih.gov/pubmed/34561474
http://dx.doi.org/10.1038/s41598-021-98097-3
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