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Primary Pericardial Epithelioid Angiosarcoma: A Diagnostic Dilemma: A Case Report
The incidence of pericardial epithelioid angiosarcoma is rare. Angiosarcoma of pericardium may coat the pericardium in a diffuse fashion. Diagnosis of an angiosarcoma is challenging and may be easily mistaken as constrictive pericarditis. Herein, a case of primary pericardial angiosarcoma is reporte...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Iranian Society of Pathology
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8463766/ https://www.ncbi.nlm.nih.gov/pubmed/34567196 http://dx.doi.org/10.30699/IJP.2021.136440.2494 |
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author | Mollasharifi, Tahmineh Kazeminezhad, Behrang |
author_facet | Mollasharifi, Tahmineh Kazeminezhad, Behrang |
author_sort | Mollasharifi, Tahmineh |
collection | PubMed |
description | The incidence of pericardial epithelioid angiosarcoma is rare. Angiosarcoma of pericardium may coat the pericardium in a diffuse fashion. Diagnosis of an angiosarcoma is challenging and may be easily mistaken as constrictive pericarditis. Herein, a case of primary pericardial angiosarcoma is reported in a 16-year-old female. Patient presented with chest pain and dyspnea on exertion, regarded as constrictive pericarditis. Pericardectomy was performed and histopathologic examination showed pleomorphic epithelioid cells exhibiting hyperchromatic nuclei, prominent nucleoli and eosinophilic cytoplasm arranged in sheets and occasionally lined irregular vascular spaces. Moreover, immunohistochemical staining revealed that tumor cells were positive for CD31 and vimentin. The patient received chemotherapy with adriamycin, ifosfamide, and mesna. Unfortunately, the patient died of cardiac involvement and pleural metastases less than three months following the operation. Primary pericardial angiosarcoma is rare and difficult to diagnose, especially epithelioid variant. Immunohistochemical assessment is required to confirm the final diagnosis. |
format | Online Article Text |
id | pubmed-8463766 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Iranian Society of Pathology |
record_format | MEDLINE/PubMed |
spelling | pubmed-84637662021-09-25 Primary Pericardial Epithelioid Angiosarcoma: A Diagnostic Dilemma: A Case Report Mollasharifi, Tahmineh Kazeminezhad, Behrang Iran J Pathol Case Report The incidence of pericardial epithelioid angiosarcoma is rare. Angiosarcoma of pericardium may coat the pericardium in a diffuse fashion. Diagnosis of an angiosarcoma is challenging and may be easily mistaken as constrictive pericarditis. Herein, a case of primary pericardial angiosarcoma is reported in a 16-year-old female. Patient presented with chest pain and dyspnea on exertion, regarded as constrictive pericarditis. Pericardectomy was performed and histopathologic examination showed pleomorphic epithelioid cells exhibiting hyperchromatic nuclei, prominent nucleoli and eosinophilic cytoplasm arranged in sheets and occasionally lined irregular vascular spaces. Moreover, immunohistochemical staining revealed that tumor cells were positive for CD31 and vimentin. The patient received chemotherapy with adriamycin, ifosfamide, and mesna. Unfortunately, the patient died of cardiac involvement and pleural metastases less than three months following the operation. Primary pericardial angiosarcoma is rare and difficult to diagnose, especially epithelioid variant. Immunohistochemical assessment is required to confirm the final diagnosis. Iranian Society of Pathology 2021 2020-07-06 /pmc/articles/PMC8463766/ /pubmed/34567196 http://dx.doi.org/10.30699/IJP.2021.136440.2494 Text en https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution- 4.0 International License, (https://creativecommons.org/licenses/by/4.0/) which permits Share, copy and redistribution of the material in any medium or format or adapt, remix, transform, and build upon the material for any purpose, even commercially |
spellingShingle | Case Report Mollasharifi, Tahmineh Kazeminezhad, Behrang Primary Pericardial Epithelioid Angiosarcoma: A Diagnostic Dilemma: A Case Report |
title | Primary Pericardial Epithelioid Angiosarcoma: A Diagnostic Dilemma: A Case Report |
title_full | Primary Pericardial Epithelioid Angiosarcoma: A Diagnostic Dilemma: A Case Report |
title_fullStr | Primary Pericardial Epithelioid Angiosarcoma: A Diagnostic Dilemma: A Case Report |
title_full_unstemmed | Primary Pericardial Epithelioid Angiosarcoma: A Diagnostic Dilemma: A Case Report |
title_short | Primary Pericardial Epithelioid Angiosarcoma: A Diagnostic Dilemma: A Case Report |
title_sort | primary pericardial epithelioid angiosarcoma: a diagnostic dilemma: a case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8463766/ https://www.ncbi.nlm.nih.gov/pubmed/34567196 http://dx.doi.org/10.30699/IJP.2021.136440.2494 |
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