Histone deacetylase inhibitor AR-42 and achiral analogues kill malaria parasites in vitro and in mice

Malaria is caused by infection with Plasmodium parasites and results in significant health and economic impacts. Malaria eradication is hampered by parasite resistance to current drugs and the lack of a widely effective vaccine. Compounds that target epigenetic regulatory proteins, such as histone d...

Descripción completa

Detalles Bibliográficos
Autores principales: Chua, Ming Jang, Tng, Jiahui, Hesping, Eva, Fisher, Gillian M., Goodman, Christopher D., Skinner-Adams, Tina, Do, Darren, Lucke, Andrew J., Reid, Robert C., Fairlie, David P., Andrews, Katherine T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Regular article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8463797/
https://www.ncbi.nlm.nih.gov/pubmed/34560571
http://dx.doi.org/10.1016/j.ijpddr.2021.08.006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8463797/
https://www.ncbi.nlm.nih.gov/pubmed/34560571
http://dx.doi.org/10.1016/j.ijpddr.2021.08.006

Ejemplares similares