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A Beam-Specific Optimization Target Volume for Stereotactic Proton Pencil Beam Scanning Therapy for Locally Advanced Pancreatic Cancer
PURPOSE: We investigate two margin-based schemes for optimization target volumes (OTV), both isotropic expansion (2 mm) and beam-specific OTV, to account for uncertainties due to the setup errors and range uncertainties in pancreatic stereotactic pencil beam scanning (PBS) proton therapy. Also, as 2...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8463829/ https://www.ncbi.nlm.nih.gov/pubmed/34604607 http://dx.doi.org/10.1016/j.adro.2021.100757 |
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author | Han, Dong Hooshangnejad, Hamed Chen, Chin-Cheng Ding, Kai |
author_facet | Han, Dong Hooshangnejad, Hamed Chen, Chin-Cheng Ding, Kai |
author_sort | Han, Dong |
collection | PubMed |
description | PURPOSE: We investigate two margin-based schemes for optimization target volumes (OTV), both isotropic expansion (2 mm) and beam-specific OTV, to account for uncertainties due to the setup errors and range uncertainties in pancreatic stereotactic pencil beam scanning (PBS) proton therapy. Also, as 2-mm being one of the extreme sizes of margin, we also study whether the plan quality of 2-mm uniform expansion could be comparable to other plan schemes. METHODS AND MATERIALS: We developed 2 schemes for OTV: (1) a uniform expansion of 2 mm (OTV(2mm)) for setup uncertainty and (2) a water equivalent thickness–based, beam-specific expansion (OTV(WET)) on beam direction and 2 mm expansion laterally. Six LAPC patients were planned with a prescribed dose of 33 Gy (RBE) in 5 fractions. Robustness optimization (RO) plans on gross tumor volumes, with setup uncertainties of 2 mm and range uncertainties of 3.5%, were implemented as a benchmark. RESULTS: All 3 optimization schemes achieved decent target coverage with no significant difference. The OTV(2mm) plans show superior organ at risk (OAR) sparing, especially for proximal duodenum. However, OTV(2mm) plans demonstrate severe susceptibility to range and setup uncertainties with a passing rate of 19% of the plans meeting the goal of 95% volume covered by the prescribed dose. The proposed dose spread function analysis shows no significant difference. CONCLUSIONS: The use of OTV(WET) mimics a union volume for all scenarios in robust optimization but saves optimization time noticeably. The beam-specific margin can be attractive to online adaptive stereotactic body proton therapy owing to the efficiency of the plan optimization. |
format | Online Article Text |
id | pubmed-8463829 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-84638292021-10-01 A Beam-Specific Optimization Target Volume for Stereotactic Proton Pencil Beam Scanning Therapy for Locally Advanced Pancreatic Cancer Han, Dong Hooshangnejad, Hamed Chen, Chin-Cheng Ding, Kai Adv Radiat Oncol Scientific Article PURPOSE: We investigate two margin-based schemes for optimization target volumes (OTV), both isotropic expansion (2 mm) and beam-specific OTV, to account for uncertainties due to the setup errors and range uncertainties in pancreatic stereotactic pencil beam scanning (PBS) proton therapy. Also, as 2-mm being one of the extreme sizes of margin, we also study whether the plan quality of 2-mm uniform expansion could be comparable to other plan schemes. METHODS AND MATERIALS: We developed 2 schemes for OTV: (1) a uniform expansion of 2 mm (OTV(2mm)) for setup uncertainty and (2) a water equivalent thickness–based, beam-specific expansion (OTV(WET)) on beam direction and 2 mm expansion laterally. Six LAPC patients were planned with a prescribed dose of 33 Gy (RBE) in 5 fractions. Robustness optimization (RO) plans on gross tumor volumes, with setup uncertainties of 2 mm and range uncertainties of 3.5%, were implemented as a benchmark. RESULTS: All 3 optimization schemes achieved decent target coverage with no significant difference. The OTV(2mm) plans show superior organ at risk (OAR) sparing, especially for proximal duodenum. However, OTV(2mm) plans demonstrate severe susceptibility to range and setup uncertainties with a passing rate of 19% of the plans meeting the goal of 95% volume covered by the prescribed dose. The proposed dose spread function analysis shows no significant difference. CONCLUSIONS: The use of OTV(WET) mimics a union volume for all scenarios in robust optimization but saves optimization time noticeably. The beam-specific margin can be attractive to online adaptive stereotactic body proton therapy owing to the efficiency of the plan optimization. Elsevier 2021-07-29 /pmc/articles/PMC8463829/ /pubmed/34604607 http://dx.doi.org/10.1016/j.adro.2021.100757 Text en © 2021 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Scientific Article Han, Dong Hooshangnejad, Hamed Chen, Chin-Cheng Ding, Kai A Beam-Specific Optimization Target Volume for Stereotactic Proton Pencil Beam Scanning Therapy for Locally Advanced Pancreatic Cancer |
title | A Beam-Specific Optimization Target Volume for Stereotactic Proton Pencil Beam Scanning Therapy for Locally Advanced Pancreatic Cancer |
title_full | A Beam-Specific Optimization Target Volume for Stereotactic Proton Pencil Beam Scanning Therapy for Locally Advanced Pancreatic Cancer |
title_fullStr | A Beam-Specific Optimization Target Volume for Stereotactic Proton Pencil Beam Scanning Therapy for Locally Advanced Pancreatic Cancer |
title_full_unstemmed | A Beam-Specific Optimization Target Volume for Stereotactic Proton Pencil Beam Scanning Therapy for Locally Advanced Pancreatic Cancer |
title_short | A Beam-Specific Optimization Target Volume for Stereotactic Proton Pencil Beam Scanning Therapy for Locally Advanced Pancreatic Cancer |
title_sort | beam-specific optimization target volume for stereotactic proton pencil beam scanning therapy for locally advanced pancreatic cancer |
topic | Scientific Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8463829/ https://www.ncbi.nlm.nih.gov/pubmed/34604607 http://dx.doi.org/10.1016/j.adro.2021.100757 |
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