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DNA polymerases η and κ bypass N(2)-guanine-O(6)-alkylguanine DNA alkyltransferase cross-linked DNA-peptides

DNA-protein cross-links are formed when proteins become covalently trapped with DNA in the presence of exogenous or endogenous alkylating agents. If left unrepaired, they inhibit transcription as well as DNA unwinding during replication and may result in genome instability or even cell death. The DN...

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Detalles Bibliográficos
Autores principales:	Ghodke, Pratibha P., Guengerich, F. Peter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8463853/ https://www.ncbi.nlm.nih.gov/pubmed/34461101 http://dx.doi.org/10.1016/j.jbc.2021.101124

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