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DNA polymerase θ promotes CAG•CTG repeat expansions in Huntington’s disease via insertion sequences of its catalytic domain

Huntington's disease (HD), a neurodegenerative disease characterized by progressive dementia, psychiatric problems, and chorea, is known to be caused by CAG repeat expansions in the HD gene HTT. However, the mechanism of this pathology is not fully understood. The translesion DNA polymerase θ (...

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Detalles Bibliográficos
Autores principales:	Chan, Kara Y., Li, Xueying, Ortega, Janice, Gu, Liya, Li, Guo-Min
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8463855/ https://www.ncbi.nlm.nih.gov/pubmed/34473992 http://dx.doi.org/10.1016/j.jbc.2021.101144

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