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The periodic table of ribonucleotide reductases
In most organisms, transition metal ions are necessary cofactors of ribonucleotide reductase (RNR), the enzyme responsible for biosynthesis of the 2′-deoxynucleotide building blocks of DNA. The metal ion generates an oxidant for an active site cysteine (Cys), yielding a thiyl radical that is necessa...
Autores principales: | Ruskoski, Terry B., Boal, Amie K. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Biochemistry and Molecular Biology
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8463856/ https://www.ncbi.nlm.nih.gov/pubmed/34461093 http://dx.doi.org/10.1016/j.jbc.2021.101137 |
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