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Evidence for complex dynamics during U2 snRNP selection of the intron branchpoint

Splicing of pre-mRNA is initiated by binding of U1 to the 5′ splice site and of Msl5-Mud2 heterodimer to the branch site (BS). Subsequent binding of U2 displaces Msl5-Mud2 from the BS to form the prespliceosome, a step governing branchpoint selection and hence 3′ splice site choice, and linking spli...

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Detalles Bibliográficos
Autores principales:	Kao, Ching-Yang, Cao, En-Cih, Wai, Hsu Lei, Cheng, Soo-Chen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	RNA and RNA-protein complexes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8464032/ https://www.ncbi.nlm.nih.gov/pubmed/34387687 http://dx.doi.org/10.1093/nar/gkab695

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